Results 11 to 20 of about 1,712 (131)
Biotechnology and Bioengineering, Volume 119, Issue 1, Page 145-161, January 2022., 2022 Development and application of powerful target metabolite profiling methodology to monitor how primary metabolism support precursors and energy for heterologous secondary metabolite production in Streptomyces superhost strains Abstract Microbial superhost strains should provide an ideal platform for the efficient homologous or heterologous phenotypic ...
Kanhaiya Kumar, Per Bruheim
wiley +1 more source
Epigenetics: a catalyst of plant immunity against pathogens
New Phytologist, Volume 233, Issue 1, Page 66-83, January 2022., 2022 Summary The plant immune system protects against pests and diseases. The recognition of stress‐related molecular patterns triggers localised immune responses, which are often followed by longer‐lasting systemic priming and/or up‐regulation of defences. In some cases, this induced resistance (IR) can be transmitted to following generations.
Adam Hannan Parker +2 more
wiley +1 more source
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Currently, traditional cancer therapy still falls far short of expectations. However, a variety of invasive cancers that are resistant to chemotherapy (such as platinum drugs, one of the most applied antineoplastics in clinic) and targeted agents are susceptible to ferroptosis.
Yue Cheng +4 more
wiley +1 more source
BioTechniques, 1999 Human tumor samples were screened for point mutations by adapting a mobilityshift assay to automated DNA sizing. This screen identifies the type of point mutation and relative amount of mutated DNA sequences present in a sample. Test samples having known
L.A. Marcelino +6 more
doaj +1 more source
Detection of known haemophilia B mutations and carrier testing by microarray [PDF]
, 2005 The molecular basis of haemophilia B is heterogeneous and many mutations of the Factor IX (FIX) gene have been characterised. Using the allele-specific arrayed primer extension (AS-APEX) technology, we have designed a FIX array to simultaneously analyse ...
Chan, K +8 more
core +1 more source
The RNA binding specificity of human APOBEC3 proteins resembles that of HIV-1 nucleocapsid [PDF]
, 2016 The APOBEC3 (A3) cytidine deaminases are antiretroviral proteins, whose targets include human immunodeficiency virus type-1 (HIV-1). Their incorporation into viral particles is critical for antiviral activity and is driven by interactions with the RNA ...
Bieniasz, Paul D +3 more
core +4 more sources
Altered deoxyribonucleotide pools in T-lymphoblastoid cells expressing the multisubstrate nucleoside kinase of Drosophila melanogaster [PDF]
, 2005 The multisubstrate nucleoside kinase of Drosophila melanogaster (Dm-dNK) can be expressed in human solid tumor cells and its unique enzymatic properties makes this enzyme a suicide gene candidate.
Balzarini, J +4 more
core +1 more source
Mechanism of polypurine tract primer generation by HIV-1 reverse transcriptase [PDF]
, 2018 HIV-1 reverse transcriptase (HIV-1 RT) possesses both DNA polymerase activity and RNase H activity that act in concert to convert single-stranded RNA of the viral genome to double-stranded DNA that is then integrated into the DNA of the infected cell ...
Figiel, Małgorzata +8 more
core +1 more source
Matrix gla protein in xenopus laevis: molecular cloning, tissue distribution, and evolutionary considerations [PDF]
, 2001 Matrix Gla protein (MGP) belongs to the family of vitamin K-dependent, Gla-containing proteins and in higher vertebrates, is found in the extracellular matrix of mineralized tissues and soft tissues. MGP synthesis is highly regulated at the transcription
Bassez +55 more
core +1 more source
Exciton States of Dynamic DNA Double Helices: Alternating dCdG Sequences [PDF]
, 2005 The present communication deals with the excited states of the alternating DNA oligomer (dCdG)5·(dCdG)5 which correspond to the UV absorption band around 260 nm.
Emanuele, E. +4 more
core +5 more sources