Results 71 to 80 of about 101,166 (300)
Advanced Science, EarlyView.This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian +7 more
wiley +1 more source
Unknown Areas of Activity of Human Ribonuclease Dicer: A Putative Deoxyribonuclease Activity
Molecules, 2020 The Dicer ribonuclease plays a crucial role in the biogenesis of small regulatory RNAs (srRNAs) by processing long double-stranded RNAs and single-stranded hairpin RNA precursors into small interfering RNAs (siRNAs) and microRNAs (miRNAs), respectively ...
Marta Wojnicka +2 more
doaj +1 more source
Enzymatic Changes in Serum of Benign and Malignant Brain Tumors Patients [PDF]
مجلة التربية والعلم, 2008 The present study is concerned with the investigation of the activity of some enzymes as lactate dehydrogenase (LDH), creatine kinase (CK), alkaline phosphatase (ALP), xanthine oxidase (XO), adenosine deaminase (ADA), cytidine deaminase (CDA), 5 ...
Kusay A. M. Al-Chalabi +1 more
doaj +1 more source
Highly sensitive nuclease assay based on chemically-modified DNA or RNA [PDF]
, 2014 Nucleolytic enzymes are associated with various diseases, and several methods have been developed for their detection. DNase expression is modulated in such diseases as acute myocardial infarction, transient myocardial ischemia, oral cancer, stomach ...
Sato Shinobu, Takenaka Shigeori
core +2 more sources
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
Cancer Communications, EarlyView.Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan +11 more
wiley +1 more source
Measuring and reporting quality of life outcomes in clinical trials in cystic fibrosis: a critical review [PDF]
, 2005 Good quality clinical trials are essential to inform the best cystic fibrosis (CF) management and care, by determining and comparing the effectiveness of new and existing therapies and drug delivery systems.
Abbott, Janice, Hart, Anna
core +2 more sources
Electrochemical Science Advances, EarlyView.ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley +1 more source
3’-Methyl-4-thio-1H-tetrahydropyranspiro-5’-hydantoin platinum complex as a novel deoxyribonuclease I inhibitor [PDF]
PharmaciaDeoxyribonuclease I (DNase I) is one of the main nucleases involved in deoxyribonucleic acid (DNA) degradation during apoptosis. It catalyzes the hydrolytic cleavage of DNA, producing 5‘-oligonucleotides.
Ana Marković +5 more
doaj +3 more sources
Journal of Animal Science and Biotechnology, 2022 Background Mammary health is important for transition dairy cows and has been well recognized to exert decisive effects on animal welfare. However, the factors influencing mammary health are still unclear.
Luyi Jiang +5 more
doaj +1 more source