Results 71 to 80 of about 14,183,395 (235)

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

Identification and Localization of Deoxyribonuclease I in the Rat Ovary1 [PDF]

open access: yesBiology of Reproduction, 1997
Our objective was to identify the endonuclease responsible for DNA degradation in the ovary and determine its localization relative to the developmental state of ovarian follicles. Immature rats were treated with diethylstilbestrol (DES; DES group), DES + eCG (eCG group) or DES + eCG + hCG (hCG group).
David L. Boone, Benjamin K. Tsang
openaire   +3 more sources

Targeting SPHK1 in macrophages remodels the tumor microenvironment and enhances anti‐PD‐1 immunotherapy efficacy in colorectal cancer liver metastasis

open access: yesCancer Communications, EarlyView.
Abstract Background Colorectal cancer liver metastasis (CRLM) is characterized by an immunosuppressive microenvironment and a blunted response to immunotherapy. Notably, tumor‐associated macrophages (TAMs) play a critical role in modulating immune responses and exhibit significant heterogeneity in CRLM.
Yizhi Zhan   +11 more
wiley   +1 more source

An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis

open access: yesDrug Delivery, 2023
Rheumatoid arthritis (RA), an autoimmune disease, is characterized by inflammatory cell infiltration that damages cartilage, disrupts bone, and impairs joint function.
Nan Wang   +3 more
doaj   +1 more source

Electrochemical Biosensors for Cancer Biomarker Detection: Basic Concept, Design Strategy and Cutting‐Edge Development

open access: yesElectrochemical Science Advances, EarlyView.
ABSTRACT Cancer is a result of uncontrolled cell growth with the potential to damage or spread to another part of the body. It is the deadliest disease in the world; therefore, rapid and sensitive detection is essential to fight it. In the past few decades, many diagnosis tools have been developed to detect cancer and monitor therapy progress.
Md Mobarok Karim, Tahera Lasker
wiley   +1 more source

Enzymatic Study in Sera of Chronic Renal Failure Patients Undergoing Hemodialysis [PDF]

open access: yesمجلة التربية والعلم, 1999
This study involved an estimation of the activity of some enzymes such as xanthine oxidase (X.O), acidic and alkaline deoxyribonuclease (DNase), peroxidase and pepsinogen in sera of patients with chronic renal failure (CRF) which treated with ...
Azzam Abdulsattar Mosa
doaj   +1 more source

Bioactive polysaccharides and their potential health benefits in reducing the risks of metabolic syndrome: A review

open access: yesFood Biomacromolecules, EarlyView.
Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo   +3 more
wiley   +1 more source

One-pot Synthesis of Quencher Labeled Hairpin DNA–CdTe QDs Conjugate for Target DNA and Deoxyribonuclease I Detection

open access: yesAnalytical Sciences, 2016
A black-hole quencher (BHQ-2) labeled DNA (Q-DNA) with a phosphorothioate backbone was covalently conjugated to the CdTe QDs during the QDs synthesis procedure.
Qingfeng Zhang   +4 more
semanticscholar   +1 more source

The Involvement of Neutrophil Extracellular Traps in Disease Activity Associated With IgA Vasculitis

open access: yesFrontiers in Immunology, 2021
ObjectivesThis aim of this study was to determine whether neutrophil extracellular traps (NETs) are involved in the pathogenesis of IgA vasculitis (IgAV) and investigate whether the circulating NETs levels are associated with disease activity in children.
Xiu-Qi Chen   +5 more
doaj   +1 more source

MXenes‐based flexible electronics for wound monitoring and treatment

open access: yesInterdisciplinary Medicine, EarlyView.
This article provides a comprehensive overview of recent advancements in MXenes‐based flexible electronic devices for wound monitoring. It discusses the monitoring mechanisms and values for various wound pathological parameters as well as their applications in treating bacterial infections and chronic wounds.
Ye Yang   +6 more
wiley   +1 more source

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