Results 1 to 10 of about 14,669 (270)

Role of Cell-Free DNA and Deoxyribonucleases in Tumor Progression [PDF]

International Journal of Molecular Sciences, 2021
Many studies have reported an increase in the level of circulating cell-free DNA (cfDNA) in the blood of patients with cancer. cfDNA mainly comes from tumor cells and, therefore, carries features of its genomic profile.
Л. А. Алексеева, Н. Л. Миронова   +1 more
openalex   +2 more sources

Deoxyribonucleases and Their Applications in Biomedicine

Biomolecules, 2020
Extracellular DNA, also called cell-free DNA, released from dying cells or activated immune cells can be recognized by the immune system as a danger signal causing or enhancing inflammation.
Lucia Lauková, Barbora Konečná, Ľubica Janovičová, Barbora Vlková, Peter Celec   +4 more
doaj   +2 more sources

Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity.

PLoS ONE, 2019
Deoxyribonucleases (DNases) might play a role in prevention of autoimmune conditions such as systemic lupus erythematosus through clearance of cell debris resulting from apoptosis and/or necrosis. Previous studies have suggested that variations in the in
Misuzu Ueki, Junko Fujihara, Kaori Kimura-Kataoka, Kazuo Yamada, Yoshikazu Takinami, Haruo Takeshita, Reiko Iida, Toshihiro Yasuda   +7 more
doaj   +2 more sources

Deoxyribonucleases of Pneumococcus.

Journal of Biological Chemistry, 1967
Abstract Two enzymes with deoxyribonuclease activity were isolated from Pneumococcus. One of these, an endonuclease active on both native and denatured deoxyribonucleic acid, produced 5'-phosphate-terminated fragments which, even after extensive degradation, were larger than mononucleotides.
S. Lacks, B. Greenberg
semanticscholar   +3 more sources

Studies on the Neutral Deoxyribonuclease Activity in Highly Purified Acid Deoxyribonuclease

Journal of Biological Chemistry, 1972
Abstract The presence of neutral deoxyribonuclease activity in highly purified preparation of acid deoxyribonuclease from sheep spleen (deoxyribonuclease II, EC 3.1.4.6) is described. The activity at pH 7.0 differs from the activity at pH 4.5 in its optimal ionic strength, its inhibition by tRNA, inhibition by EDTA, and activation by divalent cations ...
Hanoch Slor, Tama Lev
openalex   +3 more sources

Cell-free DNA in sepsis: from molecular insights to clinical management [PDF]

Military Medical Research
Sepsis is a dysregulated host response to infection that frequently results in fatal multiple organ dysfunction. Despite advances in clinical identification and management, both its incidence and mortality have remained persistently high.
Lei Li, Hong-Chao Huang, Yin He, Jia-Yue-Cheng Pang, Shi-Chu Xiao, Zhao-Fan Xia, Yong-Jun Zheng   +6 more
doaj   +2 more sources

Microbial enzymes as powerful natural anti-biofilm candidates [PDF]

Microbial Cell Factories
Bacterial biofilms pose significant challenges, from healthcare-associated infections to biofouling in industrial systems, resulting in significant health impacts and financial losses globally.
Lamiaa A. Al-Madboly, Asmaa Aboulmagd, Mohamed Abd El-Salam, Ivan Kushkevych, Rasha M. El-Morsi   +4 more
doaj   +2 more sources

Electrochemical sensor for blood deoxyribonucleases: Design and application to the diagnosis of autoimmune thyroiditis [PDF]

Analytical and Bioanalytical Chemistry, 2011
We designed an electrochemical sensor based on a carbon nanotube modified electrode (ME) to analyze DNA-cleaving activity. The cleavage of high molecular weight DNA resulted in an increase in the oxidation current from DNA guanine nucleotides due to a ...
Abdullin T., Saifullina D., Sattarova L., Shakhmaeva I.   +3 more
core   +2 more sources

Prophage induction in a permeabilized cell system: induction by deoxyribonucleases and the role of recBC-deoxyribonuclease [PDF]

Journal of Bacteriology, 1980
R M Irbe, M Oishi
openalex   +2 more sources

Salivary Extracellular DNA and DNase Activity in Periodontitis

Applied Sciences, 2020
Extracellular DNA (ecDNA) is a potential marker and predictor in several inflammatory diseases. Periodontitis, a chronic inflammatory disease, is associated with epithelial cell death and could lead to release of DNA.
Barbora Konečná, Alexandra Gaál Kovalčíková, Alexandra Pančíková, Bohuslav Novák, Eva Kovaľová, Peter Celec, Ľubomíra Tóthová   +6 more
doaj   +1 more source