Results 11 to 20 of about 14,551 (257)

Low genetic heterogeneity of copy number variations (CNVs) in the genes encoding the human deoxyribonucleases 1-like 3 and II potentially relevant to autoimmunity

PLoS ONE, 2019
Deoxyribonucleases (DNases) might play a role in prevention of autoimmune conditions such as systemic lupus erythematosus through clearance of cell debris resulting from apoptosis and/or necrosis. Previous studies have suggested that variations in the in
M. Ueki, J. Fujihara, Kaori Kimura-Kataoka, Kazuo Yamada, Y. Takinami, H. Takeshita, R. Iida, T. Yasuda   +7 more
semanticscholar   +2 more sources

Microbial enzymes as powerful natural anti-biofilm candidates. [PDF]

Microb Cell Fact
Bacterial biofilms pose significant challenges, from healthcare-associated infections to biofouling in industrial systems, resulting in significant health impacts and financial losses globally.
Al-Madboly LA, Aboulmagd A, El-Salam MA, Kushkevych I, El-Morsi RM.   +4 more
europepmc   +2 more sources

Nucleases in gene-editing technologies: past and prologue

National Science Open, 2023
In recent decades, gene-editing technologies, typically based on deoxyribonucleases to specifically modify genomic sequences, have dramatically remodeled various aspects of life sciences, including fundamental research, breeding, and medical therapeutics.
Li Dan-Yuan, Li Long-Qi, Liu Jun-Jie Gogo   +2 more
doaj   +1 more source

Salivary Extracellular DNA and DNase Activity in Periodontitis

Applied Sciences, 2020
Extracellular DNA (ecDNA) is a potential marker and predictor in several inflammatory diseases. Periodontitis, a chronic inflammatory disease, is associated with epithelial cell death and could lead to release of DNA.
Barbora Konečná, Alexandra Gaál Kovalčíková, Alexandra Pančíková, Bohuslav Novák, Eva Kovaľová, Peter Celec, Ľubomíra Tóthová   +6 more
doaj   +1 more source

Involvement of retroelements in the autoimmune response in humans

Exploration of Medicine, 2022
Retroelements are mobile genomic components requiring an RNA intermediate which is reverse-transcribed into complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotransposons and endogenous retroviruses ...
Sezer Okay
doaj   +1 more source

Engineering of Cytolethal Distending Toxin B by Its Reducing Immunogenicity and Maintaining Stability as a New Drug Candidate for Tumor Therapy; an In Silico Study

Toxins, 2021
The cytolethal distending toxin (CDT), Haemophilus ducreyi, is one of the bacterial toxins that have recently been considered for targeted therapies, especially in cancer therapies. CDT is an A-B2 exotoxin.
Maryam Keshtvarz, Mahdieh Mahboobi, Marek Kieliszek, Antoni Miecznikowski, Hamid Sedighian, Milad Rezaei, Mohammad Ali Haghighi, Zahra Zareh, Ehsan Rezaei   +8 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps

Scientific Reports, 2020
Group A Streptococcus (GAS) secretes deoxyribonucleases and evades neutrophil extracellular killing by degrading neutrophil extracellular traps (NETs).
Mototsugu Tanaka, Ryo Kinoshita-Daitoku, Kotaro Kiga, Takahito Sanada, Bo Zhu, Tokuju Okano, Chihiro Aikawa, Tamako Iida, Yoshitoshi Ogura, Tetsuya Hayashi, Koshu Okubo, Miho Kurosawa, Junichi Hirahashi, Toshihiko Suzuki, Ichiro Nakagawa, Masaomi Nangaku, Hitomi Mimuro   +16 more
doaj   +1 more source

Deoxyribonucleases of Pneumococcus

Journal of Biological Chemistry, 1967
Abstract Two enzymes with deoxyribonuclease activity were isolated from Pneumococcus. One of these, an endonuclease active on both native and denatured deoxyribonucleic acid, produced 5'-phosphate-terminated fragments which, even after extensive degradation, were larger than mononucleotides.
Sanford A. Lacks, Bill Greenberg
openaire   +3 more sources

Highly sensitive nuclease assay based on chemically-modified DNA or RNA [PDF]

, 2014
Nucleolytic enzymes are associated with various diseases, and several methods have been developed for their detection. DNase expression is modulated in such diseases as acute myocardial infarction, transient myocardial ischemia, oral cancer, stomach ...
Sato Shinobu, Takenaka Shigeori
core   +2 more sources