Results 41 to 50 of about 14,551 (257)

Molecular Mechanisms of Neutrophil Extracellular Trap (NETs) Degradation

International Journal of Molecular Sciences, 2023
Although many studies have been exploring the mechanisms driving NETs formation, much less attention has been paid to the degradation and elimination of these structures.
U. Demkow
semanticscholar   +1 more source

Hyaluronic acid in viscous malignant mesothelioma pleural effusion [PDF]

, 2021
© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology Malignant pleural effusion (MPE) is common with mesothelioma.
Cheah, Hui Min, Creaney, Jenette, Fitzgerald, Deirdre, Lee, Y. C.Gary, Louw, Amber   +4 more
core   +2 more sources

Transcript Identification Using Arrayed Hydrogels With TrapFISH

Advanced Materials Technologies, EarlyView.
TrapFISH is a novel method for high‐throughput single‐cell transcriptomics. It embeds cells in hyaluronic acid hydrogel beads and uses probe hybridization to quantify custom gene panels. By arraying hydrogels in microfluidic devices, cell barcoding is removed, enhancing scalability for studying cellular heterogeneity and rare cell states by targeting ...
David B. Morse, Zenon Toprakcioglu, Akhila Denduluri‐Marthi, James D. Brenton, Craig J. Thomas, Tuomas P. J. Knowles   +5 more
wiley   +1 more source

A Comparison of the Initial Actions of Spleen Deoxyrihonuclease and Pancreatic Deoxyrihonuclease [PDF]

, 1965
The modes of action of several deoxyribonucleases have been studied in varying detail. The manner in which pancreatic deoxyribonuclease degrades deoxyribonucleic acid has been thoroughly analyzed both with regard to the breakdown of secondary structure ...
Sinsheimer, Robert L., Young, Elton T., II   +1 more
core  

Discovery of a novel restriction endonuclease by genome comparison and application of a wheat-germ-based cell-free translation assay: PabI (5′-GTA/C) from the hyperthermophilic archaeon Pyrococcus abyssi [PDF]

, 2005
To search for restriction endonucleases, we used a novel plant-based cell-free translation procedure that bypasses the toxicity of these enzymes. To identify candidate genes, the related genomes of the hyperthermophilic archaea Pyrococcus abyssi and ...
Bujnicki, Janusz M., Ishikawa, Ken, Kawakami, Bunsei, Kobayashi, Ichizo, Kuroita, Toshihiro, Tanokura, Masaru, Uchiyama, Ikuo, Watanabe, Miki   +7 more
core   +2 more sources

Deoxyribonuclease Activity in Human Sperm [PDF]

Archives of Andrology, 1985
A previous failure to detect DNase activity in human sperm sonicates was ascribed to an inadequate amount of sperm used. In the present work aliquots contained more sperm (1.5-2.5/10(6)), permitting the detection of enzyme activity. The latter was significantly higher in spermatozoa of oligozoospermic origin compared with activity in normospermic ...
Rina Singer, D. Allalouf, H Levinsky, Ciro Servadio, M. Sagiv, M. Barnet   +5 more
openaire   +3 more sources

Type I Interferon Signaling Augments Autoimmunity in Neuromyelitis Optica Spectrum Disorder

Advanced Science, EarlyView.
The cGAS‐STING innate immune pathway is excessively activated both in peripheral monocytes and CNS microglia in patients with NMOSD, leading to an overproduction of IFN‐I. IFN‐I subsequently acts on AQP4‐specific autoreactive T cells. Blocking this pathway may offer novel therapeutic options for individuals with NMOSD.
Tian‐Xiang Zhang, Xiaoxiao Yang, Xue Gao, Xiaoshan Du, Xuegan Lian, Naiyuan Shao, Ye Liu, Zhenning Huang, Dongmei Jia, Alexander Y. L. Lau, Zhiguo Li, Zaal Kokaia, Fu‐Dong Shi, Chao Zhang   +13 more
wiley   +1 more source

A Genetic and Developmental Analysis of a Soluble Acid Deoxyribonuclease in Drosophila melanogaster [PDF]

, 1978
A deoxyribonuclease, called DNase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the enzyme maps genetically to 61.8 on the right arm of the third chromosome.
Detwiler, Charles, MacIntyre, Ross
core   +1 more source

Rutin as Deoxyribonuclease I Inhibitor

Chemistry & Biodiversity, 2019
AbstractDNase I inhibitory potential of water extract of nine Hypericum species (H. umbellatum, H. barbatum, H. rumeliacum, H. rochelii, H. perforatum, H. tetrapterum, H. olympicum, H. hirsutum, H. linarioides) and the most important Hypericum secondary metabolites (hypericin, hyperforin, quercetin, and rutin) was investigated.
Ana Kolarevic, Aleksandra Pavlovic, Aleksandra Djordjevic, Jelena Lazarevic, Sasa Savic, Gordana Kocic, Marko Anderluh, Andrija Smelcerovic   +7 more
openaire   +4 more sources

Src Reduces Neutrophil Extracellular Traps Generation and Resolves Acute Organ Damage

Advanced Science, EarlyView.
Src reduces neutrophil extracellular traps (NETs) generation and resolves acute organ damage. Src directly activates RAF1 by regulating phosphorylation at the Ser 621 site and mediates the RAF/MEK/ERK pathway, thereby affecting the intracellular ROS production. Alternatively, Src activates the RAF1/MEK/ERK pathway by mediating PKC phosphorylation.
Guotao Lu, Fei Han, Yaodong Wang, Chenchen Yuan, Qingtian Zhu, Tianqi Xia, Lin Chen, Xiaowu Dong, Yanbing Ding, Weiming Xiao, Yuyan Zhang, Jiajia Pan, Hongwei Xu, Weiwei Chen, Bo Tu, Wei Li, Fei Wang, Weijuan Gong, Lianghao Hu   +18 more
wiley   +1 more source