Results 91 to 100 of about 5,687,485 (286)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Existence dependency: conceptual modelling by contract. [PDF]
In Object Orientation, the Generalisation/Specialisation hierarchy and the Whole/Part relationship are prevalent classification schemes for object types.
Dedene, Guido, Snoeck, Monique
core
Origins of the dependency theory: trajectories, actors, and institutions
“Dependency” has been, at different epochs, a central theme in the Latin American intellectual field. It emerged strongly during the second half of the 19th century, around the discussions on “Mental Emancipation” and “Second Independence”.
Beigel, Maria Fernanda
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
APORTES DE RUY MAURO MARINI AO DEBATE SOBRE O ESTADO NOS PAÍSES DEPENDENTES
Caderno CRHNo presente artigo, lançamos nosso olhar para uma temática de especial relevância para o contexto político atual latino-americano – o Estado. Ao revisitar os escritos de Ruy Mauro Marini, uma das principais referências da Teoria Marxista da Dependência ...
Maíra Machado Bichir
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Dependency Theory and Its Revival in the Twenty-First Century
Latin American Research ReviewThis essay reviews the following works:
Steve Ellner
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Dependency-aware software release planning
, 2017 Dependency-aware software release ...
Davoud Mougouei (14681671) +2 more
core