Results 111 to 120 of about 5,883,864 (257)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

"Capitalism, Culture, Agency: Dependency Versus Postcolonial Theory" [PDF]

, 2002
This article reads dependency alongside and against postcolonial theory in an attempt to reinvigorate and re-validate some of the insights of the former while at the same time supporting the latter's current ascendancy in the field of Third World ...
Kapoor, Ilan
core  

Applying the theory of planned behavior and media dependency theory : predictors of public pro-environmental behavioral intentions in Singapore

, 2014
Applying the theory of planned behavior and media dependency theory, this study examines the effects of attitude, subjective norms, perceived behavioral control, media dependency, traditional media attention, Internet attention, and interpersonal ...
Rosenthal, Sonny, Ho, Shirley S., Liao, Youqing   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Task complexity and AI dependency among college students: the mediating roles of cognitive load, future anxiety, and task motivation

BMC Psychology
Purpose This study aims to clarify the associations between task complexity and Artificial Intelligence (AI) dependency among university students and to examine the roles of cognitive load, future anxiety, and task motivation in these associations ...
Hanhui Li, Fan Yang, Jinpeng Liu
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The impact of social media usage frequency on air travel behavior: an empirical analysis from China

Humanities & Social Sciences Communications
This study examines how the frequency of social media usage influences the air travel behavior of Chinese residents by integrating the Theory of Planned Behavior (TPB) and Media System Dependency (MSD) theory.
Zehao Zhang, Zhiying Zhu
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Effect of GenAI Dependency on University Students’ Academic Achievement: The Mediating Role of Self-Efficacy and Moderating Role of Perceived Teacher Caring

Behavioral Sciences
Generative artificial intelligence (GenAI) holds significant potential to enhance university students’ learning. However, over-reliance on it to complete academic tasks poses a risk to academic achievement by potentially encouraging cognitive outsourcing.
Wenxiu Jia, Li Pan, Siobhan Neary
doaj   +1 more source