Results 101 to 110 of about 5,883,864 (257)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
For a Dependency Theory in the 21st Century
Intersticios, 2018 The present work is inserted in the problematic of economic development, considering rethinking epistemological foundations of the economic theory of the dependence of certain debates of its better epoch, in order to have evaluative elements, which are ...
José Enrique Parra
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Dependency-aware software release planning
, 2017 Dependency-aware software release ...
Davoud Mougouei (14681671) +2 more
core
Origins of the dependency theory: trajectories, actors, and institutions
“Dependency” has been, at different epochs, a central theme in the Latin American intellectual field. It emerged strongly during the second half of the 19th century, around the discussions on “Mental Emancipation” and “Second Independence”.
Beigel, Maria Fernanda
core +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
Toward an Egyptian- Theory of Dependency [PDF]
بحوث إقتصادية عربية, 1992 جلال أحمد أمين
doaj +1 more source
Extraction, movement and dependency theory
, 1998 My aim in this thesis is to explore the potential of a dependency-based theory of syntax to account for extraction phenomena in English. Dependency grammars differ from constituency-based theories in expressing syntactic structure through direct ...
Kreps, Christian
core
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source