Results 71 to 80 of about 1,481 (197)

New Depsides From the Lichen Lecanora planaica

, 1994
The new depsides hyperplanaic acid (4), isohyperplanaic acid (5) and superplanaic acid (6) have been detected in the lichen Lecanora planaica and the structure of these metabolites has been established by unambiguous synthesis.
CE Barclay, JA Elix, HT Lumbsch
core   +1 more source

Intramolecular transesterification of depsides yields fluorescent 1H-isochromen-1-ones: Application as a chemical probe for lichen determination

, 2022
International audienceThe reactivity of eight purified depsides obtained from six european lichens and that display as 2-oxoalkyl chain in ortho-position of the ester bond was explored.
Ferron, S., Jéhan, P, Guillory, X., Uriac, P, Uriac, P., Ferron, S, J, P., Guillory, X, ehan   +8 more
core   +1 more source

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
The polyketide synthase ThiA that forms the heterotrimeric fungal depside thielavin A (1) has been identified and characterized. The thioesterase (TE) domain of ThiA was found to perform two consecutive esterification reactions as well as subsequent hydrolysis, and a plausible reaction mechanism for the TE‐catalyzed reactions has been proposed ...
Qiaolin Ji, Hao Xiang, Wei‐Guang Wang, Yudai Matsuda   +3 more
wiley   +2 more sources

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

Molecules, 2021
The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens.
Katarzyna Papierska, Violetta Krajka-Kuźniak, Jarosław Paluszczak, Robert Kleszcz, Marcin Skalski, Elżbieta Studzińska-Sroka, Wanda Baer-Dubowska   +6 more
doaj   +1 more source

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism

MedComm, Volume 6, Issue 11, November 2025.
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailability and successfully suppressed the tumor growth. ABSTRACT Lichen secondary metabolites have shown potential in cancer therapy, but strategies to enhance ...
Mücahit Varlı, Young Hyun Yu, Jieun Yu, Suresh R. Bhosle, Sang Kyum Kim, Yoon Gyoon Kim, Hyung‐Ho Ha, Hangun Kim   +7 more
wiley   +1 more source

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Environmental Microbiology, Volume 27, Issue 6, June 2025.
This analysis of 794 publicly available lichen shotgun metagenomic datasets, covering 467 unique lichen species from 34 countries, revealed that lichens are complex holobionts. They harbour a variety of fungal, algal, and bacterial players with remarkable biosynthetic capabilities.
Samantha C. Waterworth, Susan Egbert, John Sorensen, Barry R. O'Keefe, John A. Beutler   +4 more
wiley   +1 more source

New Depsides From Dimelaena Lichens

, 1988
The new depsides 3-chlorostenosporic acid (2), 3-chloroperlatolic acid (3) and subsphaeric acid (24) have been detected in Dimelaena lichens and the structures of the metabolites have been established by unambiguous synthesis.
JA Elix, JE Evans, TH Nash
core   +1 more source

Evernic Acid: A Low‐Toxic and Selective Alternative to Chemotherapeutic Agents in the Treatment of Ovarian Cancer

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
The potential therapeutic effects of evernic acid (EA) were investigated using functional in vitro assays and the evaluation of gene and protein expression levels on ovarian cancer cell lines. EA demonstrated antiproliferative effects on ovarian cancer cells, primarily through the activation of apoptosis at both cellular and molecular levels.
Mine Ensoy, Damla Nur Parıltı, Ayşe Hale Alkan, Kübra Nur Kaplan İlhan, Pelin Mutlu, Bala Gür Dedeoğlu, Demet Cansaran‐Duman   +6 more
wiley   +1 more source

Synthesis of meta-Divarinol and Olivetol depsides

, 1975
Unambiguous syntheses of the lichen depsides scrobiculin, sekikaic acid, homosekikaic acid, boninic acid, ramalinolic acid, paludosic acid, merochlorophaeic acid, cryptochlorophaeic acid and 4-O- methylcryptochlorophaeic acid are reported.
S Norfolk, JA Elix
core   +1 more source

Synthesis of the Lichen Depsides Miriquidic Acid and Normiriquidic Acid

, 1986
The total synthesis of the lichen depsides miriquidic acid (1) and normiriquidic acid (2) is reported. The latter depside has been shown to co-occur with miriquidic acid in the lichen Lecidea leucophaea ( Flk .) Nyl .
JA Elix, VK Jayanthi
core   +1 more source