Results 51 to 60 of about 1,182 (166)

Causes of delayed angiosperm diversification: The photosynthetic revolution, increased opportunity costs of anti‐herbivore defenses, selection for qualitative toxins, and acceleration of plant–herbivore coevolution

American Journal of Botany, Volume 112, Issue 11, November 2025.
Abstract Why did it take so long for angiosperms to diversify after they arose? Here I consider the indirect but potentially crucial impact of the “photosynthetic revolution” on plant–herbivore coevolution. Increased vein density in fossil leaves implies a doubling in photosynthesis 125–100 million years ago.
Thomas J. Givnish
wiley   +1 more source

depsides

, 2014
Citation: 'depsides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.D01603 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A

Angewandte Chemie, Volume 136, Issue 20, May 13, 2024.
The polyketide synthase ThiA that forms the heterotrimeric fungal depside thielavin A (1) has been identified and characterized. The thioesterase (TE) domain of ThiA was found to perform two consecutive esterification reactions as well as subsequent hydrolysis, and a plausible reaction mechanism for the TE‐catalyzed reactions has been proposed ...
Qiaolin Ji, Hao Xiang, Wei‐Guang Wang, Yudai Matsuda   +3 more
wiley   +2 more sources

Xerophytic Lichens from Gypsiferous Outcrops of Arid Areas of Andalusia as a Source of Anti-Phytopathogenic Depsides

Journal of Fungi, 2023
In a survey to evaluate the potential of lichens associated with gypsum areas as sources of new antifungal metabolites, six species of lichens were collected in the gypsum outcrops of the Sorbas Desert (Diploschistes ocellatus and Seirophora lacunosa ...
Ignacio Fernández-Pastor, Victor González-Menéndez, Kevin Martínez Andrade, Rachel Serrano, Thomas A. Mackenzie, Guillermo Benítez, Manuel Casares-Porcel, Olga Genilloud, Fernando Reyes   +8 more
doaj   +1 more source

Synthesized Depside Molecules Suppress the Progression of Colorectal Cancer by Binding VDAC1/PHB/MMP9 Being at the Crossroads of Stemness, Motility, Apoptosis, and Metabolism

MedComm, Volume 6, Issue 11, November 2025.
This study suggests that newly synthesized depside compounds suppress the progression of colorectal cancer by directly targeting VDAC1/PHB/MMP9. Especially, SB4 demonstrated significant bioavailability and successfully suppressed the tumor growth. ABSTRACT Lichen secondary metabolites have shown potential in cancer therapy, but strategies to enhance ...
Mücahit Varlı, Young Hyun Yu, Jieun Yu, Suresh R. Bhosle, Sang Kyum Kim, Yoon Gyoon Kim, Hyung‐Ho Ha, Hangun Kim   +7 more
wiley   +1 more source

Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells

Molecules, 2021
The study aimed to evaluate the possible modulation of Nrf2, NF-ĸB and STAT3 signaling pathways in the colorectal cancer (CRC) cells line DLD-1 and HCT116 by secondary metabolites of lichens.
Katarzyna Papierska, Violetta Krajka-Kuźniak, Jarosław Paluszczak, Robert Kleszcz, Marcin Skalski, Elżbieta Studzińska-Sroka, Wanda Baer-Dubowska   +6 more
doaj   +1 more source

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Environmental Microbiology, Volume 27, Issue 6, June 2025.
This analysis of 794 publicly available lichen shotgun metagenomic datasets, covering 467 unique lichen species from 34 countries, revealed that lichens are complex holobionts. They harbour a variety of fungal, algal, and bacterial players with remarkable biosynthetic capabilities.
Samantha C. Waterworth, Susan Egbert, John Sorensen, Barry R. O'Keefe, John A. Beutler   +4 more
wiley   +1 more source

Evernic Acid: A Low‐Toxic and Selective Alternative to Chemotherapeutic Agents in the Treatment of Ovarian Cancer

Archiv der Pharmazie, Volume 358, Issue 5, May 2025.
The potential therapeutic effects of evernic acid (EA) were investigated using functional in vitro assays and the evaluation of gene and protein expression levels on ovarian cancer cell lines. EA demonstrated antiproliferative effects on ovarian cancer cells, primarily through the activation of apoptosis at both cellular and molecular levels.
Mine Ensoy, Damla Nur Parıltı, Ayşe Hale Alkan, Kübra Nur Kaplan İlhan, Pelin Mutlu, Bala Gür Dedeoğlu, Demet Cansaran‐Duman   +6 more
wiley   +1 more source

Phenolic Acids and Depsides from Some Species of the Erodium Genera [PDF]

Zeitschrift für Naturforschung C, 2001
Abstract Six natural polyphenolic compounds, brevifolin carboxylic acid, brevifolin, ellagic acid, methyl gallate, gallic acid and protocatechuic acid have been isolated from the methanol extract of the whole plant of Erodium cicutarium (L.) L.’Herit. (Geraniaceae).
I, Fecka, A, Kowalczyk, W, Cisowski
openaire   +2 more sources

Breaking into nature's secret medicine cabinet: lichens – a biochemical goldmine ready for discovery

New Phytologist, Volume 246, Issue 2, Page 437-449, April 2025.
Summary Secondary metabolites are a crucial source of bioactive compounds playing a key role in the development of new pharmaceuticals. Recently, biosynthetic research has benefited significantly from progress on various fronts, including reduced sequencing costs, improved genome/metabolome mining strategies, and expanding tools/databases to compare ...
Garima Singh, Francesco Dal Grande, Francis M. Martin, Marnix H. Medema   +3 more
wiley   +1 more source