Results 31 to 40 of about 1,481 (197)

The aquastatin biosynthetic gene cluster encodes a versatile polyketide synthase capable of synthesising heteromeric depsides with diverse alkyl side chains. [PDF]

Chem Sci
Depsides have garnered substantial interest due to the diverse biological activities exhibited by members of this class. Among these are the antibacterial aquastatins, glycosylated heteromeric depsides formed through the condensation of orsellinic acid ...
Sbaraini N, Crombie A, Kalaitzis JA, Vuong D, Bracegirdle J, Windsor F, Lau A, Chen R, Tan YP, Lacey A, Lacey E, Piggott AM, Chooi YH.   +12 more
europepmc   +2 more sources

Lichen Polyphenolic Compounds for the Eradication of Candida albicans Biofilms

Frontiers in Cellular and Infection Microbiology, 2021
Lichens, due to their symbiotic nature (association between fungi and algae), constitute a chemical factory of original compounds. Polyphenolic compounds (depsides and depsidones) are the main constituents of lichens and are exclusively biosynthesized by
Marion Girardot, Marion Millot, Guillaume Hamion, Jeanne-Louise Billard, Camille Juin, G M A Ndong Ntoutoume, Vincent Sol, Lengo Mambu, Christine Imbert   +8 more
doaj   +1 more source

Comparison of Aqueous and Lactobacterial-Fermented Mercurialis perennis L. (Dog’s Mercury) Extracts with Respect to Their Immunostimulating Activity

Fermentation, 2023
Lactic acid (LA) fermentation of dog’s mercury (M. perennis L.) herbal parts was investigated in samples inoculated with either Lactobacteria (Lactobacillus plantarum and Pediococcus pentosaceus, LBF) or whey (WF).
Peter Lorenz, Ilona Zilkowski, Lilo K. Mailänder, Iris Klaiber, Sven Nicolay, Manuel Garcia-Käufer, Amy M. Zimmermann-Klemd, Claudia Turek, Florian C. Stintzing, Dietmar R. Kammerer, Carsten Gründemann   +10 more
doaj   +1 more source

A Candidate Gene Cluster for the Bioactive Natural Product Gyrophoric Acid in Lichen-Forming Fungi

Microbiology Spectrum, 2022
Natural products of lichen-forming fungi are structurally diverse and have a variety of medicinal properties. Despite this, they have limited implementation in industry mostly because the corresponding genes are unknown for most of their natural products.
Garima Singh, Anjuli Calchera, Dominik Merges, Henrique Valim, Jürgen Otte, Imke Schmitt, Francesco Dal Grande   +6 more
doaj   +1 more source

Two New Fumarprotocetraric Acid Lactones Identified and Characterized by UHPLC-PDA/ESI/ORBITRAP/MS/MS from the Antarctic Lichen Cladonia metacorallifera

Separations, 2022
Lichens are symbiotic organisms between algae and fungi, which are makers of secondary compounds named as lichen substances. Hyphenated techniques have significantly helped natural product chemistry, especially UHPLC/ESI/MS/MS in the identification ...
Beatriz Sepúlveda, Alberto Cornejo, Daniela Bárcenas-Pérez, José Cheel, Carlos Areche   +4 more
doaj   +1 more source

Biosynthesis of the C-Glycosylated Depside Arenicolin B. [PDF]

Chembiochem
AbstractWe uncovered the biosynthetic pathway of the C‐glycosylated depside arenicolin B from Phialomyces arenicola through genome mining, heterologous reconstitution and biochemical characterization. The biosynthetic gene cluster (BGC) of arenicolin B is comprised of a HRPKS, a NRPKS, and a C‐glycosyltransferase.
Johnson CW, Nuniz L, Perlatti B, Bills GF, Tang Y.   +4 more
europepmc   +4 more sources

UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities of Himantormia lugubris from Antarctica

Metabolites, 2022
Himantormia lugubris is a Chilean native small lichen shrub growing in the Antarctica region. In this study, the metabolite fingerprinting and the antioxidant and enzyme inhibitory potential from this species and its four major isolated compounds were ...
Carlos Areche, Javier Romero Parra, Beatriz Sepulveda, Olimpo García-Beltrán, Mario J. Simirgiotis   +4 more
doaj   +1 more source

A Photochemical Entry to Depsides: Synthesis of Gustastatin. [PDF]

ChemInform, 2005
Herein, we propose a modular and general strategy to construct orcinol-type depsides based on the photolysis of functionalized benzodioxinones (I). Notably, resorcinylic esters are obtained without competing isocoumarin (II) formation, exemplified by the first total synthesis of gustastatin in 10 steps from commercially available trihydroxybenzoic acid.
Jorge, García-Fortanet, John R, Debergh, Jef K, De Brabander   +2 more
openaire   +2 more sources

Anti-Osteoclastogenic and Antibacterial Effects of Chlorinated Polyketides from the Beibu Gulf Coral-Derived Fungus Aspergillus unguis GXIMD 02505

Marine Drugs, 2022
One new depsidone derivative, aspergillusidone H (3), along with seven known biosynthetically related chlorinated polyketides, were obtained from the Beibu Gulf coral-derived fungus Aspergillus unguis GXIMD 02505.
Yanting Zhang, Zhichao Li, Bingyao Huang, Kai Liu, Shuai Peng, Xinming Liu, Chenghai Gao, Yonghong Liu, Yanhui Tan, Xiaowei Luo   +9 more
doaj   +1 more source

Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored

Biomolecules, 2022
Aspergillus unguis belongs to the Aspergillus section Nidulantes. This species is found in soils and organisms from marine environments, such as jellyfishes and sponges. The first chemical study reported in the literature dates from 1970, with depsidones
Levy Tenório Sousa Domingos, Raquel dos Santos Martins, Leonardo Melo de Lima, Angela Michelato Ghizelini, Antonio Ferreira-Pereira, Fernando Cotinguiba   +5 more
doaj   +1 more source