Results 211 to 220 of about 9,955 (253)

The Changing Face of HDAC Inhibitor Depsipeptide

Current Cancer Drug Targets, 2009
Histone deacetylase (HDAC) inhibitors are currently used in the study of epigenetics and have potential in clinical cancer therapy. A novel and potent HDAC inhibitor, depsipeptide, also known as FK228 or FR901228, is highly efficient in inhibiting the activity of HDACs even at nanomolar concentrations.
Wen, Zhou, Wei-Guo, Zhu
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Fungal cyclooligomer depsipeptides

Natural Product Reports, 2011
This review surveys the biological activities and the iterative and recursive biosynthetic mechanisms of fungal cyclooligomer depsipeptides, and their structural diversification by various combinatorial biosynthetic methods.
Süssmuth, Roderich, Müller, Jane, Von Döhren, Hans, Molnár, István   +3 more
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Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters

The Journal of Organic Chemistry, 2011
Reactions of O-Pg(α-hydroxyacyl)benzotriazoles with (a) unprotected α-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters, (b) depsidipeptides, and (c) amide conjugates (yields 52-94%). N-Pg(α-Aminoacyl)benzotriazoles reacted with α-hydroxycarboxylic acids to yield depsidipeptides (47-87%).
Avan, İlker, Tala, Srinivasa R., Steel, Peter J., Katritzky, Alan R.   +3 more
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Cyclic depsipeptides as potential cancer therapeutics

Anti-Cancer Drugs, 2015
Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki, Genbin, Shi, Shizuka, Miyauchi, Shinya, Murakami, Yili, Yang   +4 more
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Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis

Nature Chemical Biology, 2020
D. Alonzo, C. Chiche-Lapierre, M. Tarry, Jimin Wang, T. Schmeing   +4 more
semanticscholar   +1 more source

Interactions of antimitotic peptides and depsipeptides with tubulin

Peptide Science, 2002
AbstractTubulin is the target for an ever increasing number of structurally unusual peptides and depsipeptides isolated from a wide range of organisms. Since tubulin is the subunit protein of microtubules, the compounds are usually potently toxic to mammalian cells.
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The organization of multifunctional peptide and depsipeptide synthetases

Biochemical Society Transactions, 1993
From 1987 onwards, a superfamily of acyl adenylate-forming enzymes, including acyl-CoA synthetases, peptide synthetases and amino acid-adding enzymes, has been identified from sequence data [ l] (Table 1). It now has been possible to relate these structurally to other acyl adenylate formers such as amino acyl-tRNA synthetases 121, and to several ...
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Depsipeptides

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1962
M. M. Shemyakin, Yu. A. Ovchinnikov, A. A. Kiryushkin, V. T. Ivanov   +3 more
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Zur Synthese cyclischer Depsipeptide

Chemische Berichte, 1966
AbstractSynthesen linearer Tetradepsipeptide mit D‐Valin und α‐D‐Hydroxy‐isovaleriansäure als Bausteinen (vom Typ 8 bzw. 11 bzw. 16) werden beschrieben. Die Cyclisierung gelingt nur durch Herstellung einer Amidbindung mittels der Säurechloridmethode, und sie ergibt unter Dimerisierung das Cyclooctadepsipeptid.
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Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.

Journal of antibiotics (Tokyo. 1968), 2017
S. Kitani, Tatsuya Ueguchi, Y. Igarashi, Kantinan Leetanasaksakul, A. Thamchaipenet, T. Nihira   +5 more
semanticscholar   +1 more source