Results 181 to 190 of about 3,583 (208)

Depsipeptides Communication 31. Synthesis of depsipeptides containing ?-hydroxy ?-amino acid residues

Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 1965
Depsipeptides containing α-hydroxy α-amino acid residues as hydroxy-acid component were synthesized.
G. A. Ravdel', N. A. Krit, V. A. Oladkina, L. A. Shchukina, M. M. Shemyakin   +4 more
openaire   +1 more source

Total Synthesis of the Antifungal Depsipeptide Petriellin A

The Journal of Organic Chemistry, 2011
We report the solid-phase total synthesis of the antifungal highly modified cyclic depsipeptide petriellin A. The synthesis confirms earlier reports on the absolute configuration of the natural product. The solid-phase approach resulted in a protected linear precursor, which was cleaved from the solid support prior to cyclization and final deprotection.
Sleebs, MM, Scanlon, D, Karas, J, Maharani, R, Hughes, AB   +4 more
openaire   +3 more sources

The Changing Face of HDAC Inhibitor Depsipeptide

Current Cancer Drug Targets, 2009
Histone deacetylase (HDAC) inhibitors are currently used in the study of epigenetics and have potential in clinical cancer therapy. A novel and potent HDAC inhibitor, depsipeptide, also known as FK228 or FR901228, is highly efficient in inhibiting the activity of HDACs even at nanomolar concentrations.
Wen, Zhou, Wei-Guo, Zhu
openaire   +2 more sources

Benzotriazole-Mediated Syntheses of Depsipeptides and Oligoesters

The Journal of Organic Chemistry, 2011
Reactions of O-Pg(α-hydroxyacyl)benzotriazoles with (a) unprotected α-hydroxycarboxylic acids, (b) amino acids, and (c) amines afforded, respectively, chirally pure (a) oligoesters, (b) depsidipeptides, and (c) amide conjugates (yields 52-94%). N-Pg(α-Aminoacyl)benzotriazoles reacted with α-hydroxycarboxylic acids to yield depsidipeptides (47-87%).
Avan, İlker, Tala, Srinivasa R., Steel, Peter J., Katritzky, Alan R.   +3 more
openaire   +3 more sources

Cyclic depsipeptides as potential cancer therapeutics

Anti-Cancer Drugs, 2015
Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki, Genbin, Shi, Shizuka, Miyauchi, Shinya, Murakami, Yili, Yang   +4 more
openaire   +2 more sources

The organization of multifunctional peptide and depsipeptide synthetases

Biochemical Society Transactions, 1993
From 1987 onwards, a superfamily of acyl adenylate-forming enzymes, including acyl-CoA synthetases, peptide synthetases and amino acid-adding enzymes, has been identified from sequence data [ l] (Table 1). It now has been possible to relate these structurally to other acyl adenylate formers such as amino acyl-tRNA synthetases 121, and to several ...
openaire   +2 more sources

Depsipeptides

Bulletin of the Academy of Sciences of the USSR Division of Chemical Science, 1962
M. M. Shemyakin, Yu. A. Ovchinnikov, A. A. Kiryushkin, V. T. Ivanov   +3 more
openaire   +2 more sources

Zur Synthese cyclischer Depsipeptide

Chemische Berichte, 1966
AbstractSynthesen linearer Tetradepsipeptide mit D‐Valin und α‐D‐Hydroxy‐isovaleriansäure als Bausteinen (vom Typ 8 bzw. 11 bzw. 16) werden beschrieben. Die Cyclisierung gelingt nur durch Herstellung einer Amidbindung mittels der Säurechloridmethode, und sie ergibt unter Dimerisierung das Cyclooctadepsipeptid.
openaire   +1 more source

Die Chemie der Depsipeptide

Angewandte Chemie, 1960
AbstractGegenwärtig ist eine bedeutende Anzahl natürlicher Depsipeptide (Verbindungen, die aus ester‐ und amidartig miteinander verknüpften α‐Hydroxy‐ und α‐Aminosäuren bestehen) bekannt. Diejenigen Depsipeptide, deren Konstitution aufgeklärt werden konnte, haben eine cyclische Struktur.
openaire   +1 more source

Trikoveramides A-C, cyclic depsipeptides from the marine cyanobacterium Symploca hydnoides

Phytochemistry, 2021
Ma Yadanar Phyo, Lik Tong Tan
exaly