Results 181 to 190 of about 5,584 (214)

Depsipeptides from Metarhizium anisopliae

Phytochemistry, 1981
Abstract From the culture medium of a strain of Metarhizium anisopliae , 14 depsipeptides have been isolated. Five of them were identified as known destruxins A, B, C, D and desmethyldestruxin B. The structures of the new compounds, named destruxins E, A 1 , A 2 , B 1 , B 2 , C 2 , D 1 , D 2 and E 1 ,were established mainly from the mass spectral ...
Pais, M., Das, B.C., Ferron, P.
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Total Synthesis of Antitumor Depsipeptide (−)-Doliculide

Organic Letters, 2001
[reaction: see text] (-)-Doliculide, a potent antitumor agent, is synthesized stereoselectively in a convergent manner. The key strategy involves a stereoselective synthesis of the polyketide unit and synthesis of the D-tyrosine derivative, followed by assembly of the fragments by an esterification and cycloamidation reaction sequence. The synthesis of
A K, Ghosh, C, Liu
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Cyclic depsipeptides as potential cancer therapeutics

Anti-Cancer Drugs, 2015
Cyclic depsipeptides are polypeptides in which one or more amino acid is replaced by a hydroxy acid, resulting in the formation of at least one ester bond in the core ring structure. Many natural cyclic depsipeptides possessing intriguing structural and biological properties, including antitumor, antifungal, antiviral, antibacterial, anthelmintic, and ...
Jirouta, Kitagaki, Genbin, Shi, Shizuka, Miyauchi, Shinya, Murakami, Yili, Yang   +4 more
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Biosynthesis of depsipeptide mycotoxins in Fusarium

European Journal of Plant Pathology, 2002
The cyclic hexadepsipeptide enniatin is known as a phytopathogenic compound from Fusaria causing necrosis and wilt. The molecule consists of three alternating residues each of a branched chain amino acid and D-hydroxyisovaleric acid (D-Hiv). Enniatins are synthesized by a 347kDa multienzyme (enniatin synthetase) via a thiol template mechanism.
Till Hornbogen, Mirko Glinski, Rainer Zocher   +2 more
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The structure-antimicrobial relation of depsipeptides

Experientia, 1963
Die Beziehungen zwischen Struktur und antimikrobieller Aktivitat in der Reihe der Depsipeptide wurden untersucht. Cyclotetradepsipeptide sind praktisch inaktiv. Die grosste Aktivitat besitzen die Cyclohexadepsipeptide mit regularer Oxy- und Aminosaurensequenz.
M M, SHEMYARKIN, Iu A, OVCHINNIKOV, V T, IVANOV, A A, KIRYUSHKIN, G L, ZHDANOV, I D, RYABOVA   +5 more
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Self‐Assembly of Chiral Depsipeptide Dendrimers

Chemistry – A European Journal, 2006
AbstractThe self‐assembly of chiral depsipeptide dendrons 4, which contain a cyanuric acid building block at their focal point, with the homotritopic Hamilton receptor 1 is reported. The 1:3 compositions of the resulting chiral supramolecular dendrimers, the association constants Kn, and the cooperativity of binding expressed by Scatchard plots and the
Kristine, Hager, Alexander, Franz, Andreas, Hirsch   +2 more
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Xentrivalpeptides A–Q: Depsipeptide Diversification in Xenorhabdus

Journal of Natural Products, 2012
Seventeen depsipeptides, xentrivalpeptides A-Q (1-17), have been identified from an entomopathogenic Xenorhabdus sp. Whereas the structure of xentrivalpeptide A (1) was determined after its isolation by NMR spectroscopy and the advanced Marfey's method, the structures of all other derivatives were determined using a combination of stable isotope ...
Zhou, Q., Dowling, A., Heide, H., Wohnert, J., Brandt, U., Brandt, U., Baum, J., Ffrench-Constant, R., Bode, H.B.   +8 more
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Zur Synthese cyclischer Depsipeptide

Chemische Berichte, 1966
AbstractSynthesen linearer Tetradepsipeptide mit D‐Valin und α‐D‐Hydroxy‐isovaleriansäure als Bausteinen (vom Typ 8 bzw. 11 bzw. 16) werden beschrieben. Die Cyclisierung gelingt nur durch Herstellung einer Amidbindung mittels der Säurechloridmethode, und sie ergibt unter Dimerisierung das Cyclooctadepsipeptid.
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Die Chemie der Depsipeptide

Angewandte Chemie, 1960
AbstractGegenwärtig ist eine bedeutende Anzahl natürlicher Depsipeptide (Verbindungen, die aus ester‐ und amidartig miteinander verknüpften α‐Hydroxy‐ und α‐Aminosäuren bestehen) bekannt. Diejenigen Depsipeptide, deren Konstitution aufgeklärt werden konnte, haben eine cyclische Struktur.
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The structure-antimicrobial relation for valinomycin depsipeptides

Experientia, 1965
Auf Grund eines grossen Vergleichsmaterials wurden die Strukturelemente, die fur die antimikrobielle Aktivitat der Cyclodepsipeptide notig sind, ermittelt. Insbesondere wurden Ringgrosse, Ersatz der Ester- oder N-Methylamid-Gruppe durch eine Amidgruppe, strukturelle und konfigurative Anderung der Aminosaure- und Hydroxysaurereste studiert.
M M, Shemyakin, E I, Vinogradova, M Y, Feigina, N A, Aldanova, N E, Loginova, I D, Ryabova, I A, Pavlenko   +6 more
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