Results 171 to 180 of about 3,583 (208)

The Cyclic Depsipeptide Backbone of the Didemnins

Acta Crystallographica Section C Crystal Structure Communications, 1995
An X-ray crystal analysis of phi-lactone N-¿1-¿N-¿4-¿[3- hydroxy-5-methyl-1-oxo-4-(N-L-threonylamino)heptyl]- oxy¿-2,5-dimethyl-1,3-dioxohexyl¿-L-leucyl¿-L-prolyl¿- N,O-dimethyl-L-tyrosine hydrobromide hydrate (1a), C42H66N5O11+.Br-.H2O, was obtained in order to determine the backbone folding of the macrocycle and to compare the results obtained with ...
S C, Mayer, P J, Carroll, M M, Joullié
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The structure-antimicrobial relation of depsipeptides

Experientia, 1963
Die Beziehungen zwischen Struktur und antimikrobieller Aktivitat in der Reihe der Depsipeptide wurden untersucht. Cyclotetradepsipeptide sind praktisch inaktiv. Die grosste Aktivitat besitzen die Cyclohexadepsipeptide mit regularer Oxy- und Aminosaurensequenz.
M M, SHEMYARKIN, Iu A, OVCHINNIKOV, V T, IVANOV, A A, KIRYUSHKIN, G L, ZHDANOV, I D, RYABOVA   +5 more
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Biosynthesis of depsipeptide mycotoxins in Fusarium

European Journal of Plant Pathology, 2002
The cyclic hexadepsipeptide enniatin is known as a phytopathogenic compound from Fusaria causing necrosis and wilt. The molecule consists of three alternating residues each of a branched chain amino acid and D-hydroxyisovaleric acid (D-Hiv). Enniatins are synthesized by a 347kDa multienzyme (enniatin synthetase) via a thiol template mechanism.
Till Hornbogen, Mirko Glinski, Rainer Zocher   +2 more
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Cyclic Depsipeptides, Callipeltins

2020
Marine sponges are considered as an untapped reservoir of biologically active natural compounds exhibiting numerous interesting and potentially useful pharmacological activities, including antimicrobial, antifungal, cytotoxic, anti-inflammatory, and immunostimulatory activities.
Reda A. Abdelhamid, Hiroyuki Konno
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Xentrivalpeptides A–Q: Depsipeptide Diversification in Xenorhabdus

Journal of Natural Products, 2012
Seventeen depsipeptides, xentrivalpeptides A-Q (1-17), have been identified from an entomopathogenic Xenorhabdus sp. Whereas the structure of xentrivalpeptide A (1) was determined after its isolation by NMR spectroscopy and the advanced Marfey's method, the structures of all other derivatives were determined using a combination of stable isotope ...
Zhou, Q., Dowling, A., Heide, H., Wohnert, J., Brandt, U., Brandt, U., Baum, J., Ffrench-Constant, R., Bode, H.B.   +8 more
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Synthese geschützter Depsipeptide

Helvetica Chimica Acta, 1960
AbstractThe syntheses and properties of p‐nitrobenzyl diazoacetyl‐glycinate (VI), p‐nitrobenzyl p‐(p‐methoxyphenylazo)‐benzyloxycarbonyl‐glycyl‐glycollyl‐glycinate (II) and p‐nitrobenzyl p‐phenylazo‐benzyloxycarbonyl‐glycyl‐glycollyl‐glycinate are described. These compounds have been prepared as intermediates for the synthesis of other depsipeptides.
R. Schwyzer, J. P. Carrión
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Interactions of antimitotic peptides and depsipeptides with tubulin

Biopolymers, 2002
AbstractTubulin is the target for an ever increasing number of structurally unusual peptides and depsipeptides isolated from a wide range of organisms. Since tubulin is the subunit protein of microtubules, the compounds are usually potently toxic to mammalian cells.
Ernest Hamel
exaly   +3 more sources

The structure-antimicrobial relation for valinomycin depsipeptides

Experientia, 1965
Auf Grund eines grossen Vergleichsmaterials wurden die Strukturelemente, die fur die antimikrobielle Aktivitat der Cyclodepsipeptide notig sind, ermittelt. Insbesondere wurden Ringgrosse, Ersatz der Ester- oder N-Methylamid-Gruppe durch eine Amidgruppe, strukturelle und konfigurative Anderung der Aminosaure- und Hydroxysaurereste studiert.
M M, Shemyakin, E I, Vinogradova, M Y, Feigina, N A, Aldanova, N E, Loginova, I D, Ryabova, I A, Pavlenko   +6 more
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Total Synthesis of Antitumor Depsipeptide (−)-Doliculide

Organic Letters, 2001
[reaction: see text] (-)-Doliculide, a potent antitumor agent, is synthesized stereoselectively in a convergent manner. The key strategy involves a stereoselective synthesis of the polyketide unit and synthesis of the D-tyrosine derivative, followed by assembly of the fragments by an esterification and cycloamidation reaction sequence. The synthesis of
A K, Ghosh, C, Liu
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Self‐Assembly of Chiral Depsipeptide Dendrimers

Chemistry – A European Journal, 2006
AbstractThe self‐assembly of chiral depsipeptide dendrons 4, which contain a cyanuric acid building block at their focal point, with the homotritopic Hamilton receptor 1 is reported. The 1:3 compositions of the resulting chiral supramolecular dendrimers, the association constants Kn, and the cooperativity of binding expressed by Scatchard plots and the
Kristine, Hager, Alexander, Franz, Andreas, Hirsch   +2 more
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