Results 41 to 50 of about 3,944 (245)
Methods and Methodologies for Congestion Alleviation in the DPS: A Comprehensive Review
Energies, 2023 The modern power system has reached its present state after wading a long path facing several changes in strategies and the implementation of several reforms.
Anurag Gautam +4 more
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Environment InternationalVolcanic eruptions release particles in a range of sizes that can chronically affect the health of communities within tens of kilometers of the volcano.
Lucie Sauzéat +4 more
doaj +1 more source
Microbes, Infection and Chemotherapy, 2023 TSince the onset of the SARS-CoV-2 pandemic, there has been a significant advancement in our ability to intervene in specific immunological pathways, supported by compelling evidence.
Jorge Luis Vélez Paez
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Polypharmacology of dopamine D1-like receptor antagonists [PDF]
Arhiv za farmaciju, 2015 Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases ...
Nikolić Katarina +2 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Cardiac fibroblasts regulate sympathetic nerve sprouting and neurocardiac synapse stability.
PLoS ONE, 2013 Sympathetic nervous system (SNS) plays a key role in cardiac homeostasis and its deregulations always associate with bad clinical outcomes. To date, little is known about molecular mechanisms regulating cardiac sympathetic innervation.
Céline Mias +12 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Changes in DNA Methylation in Mouse Lungs after a Single Intra-Tracheal Administration of Nanomaterials. [PDF]
PLoS ONE, 2017 This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation.Intra-tracheal administration of NM: gold nanoparticles (AuNPs) of 5-, 60- and 250-nm diameter; single-walled carbon nanotubes (SWCNTs) and multi-walled carbon ...
Ali M Tabish +9 more
doaj +1 more source