Results 41 to 50 of about 5,433 (281)
Journal of Translational Medicine, 2019 Background Leukemia stem cell (LSC)-enriched genes have been shown to be highly prognostic in acute myeloid leukemia (AML). However, the prognostic value of tumor suppressor genes (TSGs) that are repressed early in LSC remains largely unknown. Methods We
Zi-jun Xu +11 more
doaj +1 more source
Polypharmacology of dopamine D1-like receptor antagonists [PDF]
Arhiv za farmaciju, 2015 Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases ...
Nikolić Katarina +2 more
doaj +1 more source
Methods and Methodologies for Congestion Alleviation in the DPS: A Comprehensive Review
Energies, 2023 The modern power system has reached its present state after wading a long path facing several changes in strategies and the implementation of several reforms.
Anurag Gautam +4 more
doaj +1 more source
A Tailspin for Taxi Drivers: Platform Labor, Deregulations, and a Migrant Occupation
, 2022 In this article, we investigate Norwegian taxi drivers’ perceptions and experiences of the introduction of Transportation Network Companies (TNCs) such as Uber. We find that taxi drivers are highly critical, but not over technology or TNCs as such. Their
Vassenden, Anders, Staalhane, Helga Hiim
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Environment InternationalVolcanic eruptions release particles in a range of sizes that can chronically affect the health of communities within tens of kilometers of the volcano.
Lucie Sauzéat +4 more
doaj +1 more source
Microbes, Infection and Chemotherapy, 2023 TSince the onset of the SARS-CoV-2 pandemic, there has been a significant advancement in our ability to intervene in specific immunological pathways, supported by compelling evidence.
Jorge Luis Vélez Paez
doaj +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Banking Deregulations, Financing Constraints and Firm Entry Size [PDF]
We examine the effect of US branch banking deregulations on the entry size of new firms using micro-data from the US Census Bureau. We find that the average entry size for startups did not change following the deregulations.
Ramana Nanda, William R. Kerr
core +2 more sources