Results 21 to 30 of about 5,433 (281)
Research, 2022 Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy, but the survival rates of patients with ESCC have not improved as yet largely because the available targeted therapies are limited.
Gang Ma, Tongyang Gong, Zhihua Liu
doaj +1 more source
New clinical trial designs in the era of precision medicine
Molecular Oncology, 2019 Cancer treatment has made significant strides towards the promise of personalized medicine. Recent scientific advances have shown that there are numerous genetic deregulations that are common in multiple cancer types, raising the possibility of ...
Elena Garralda +5 more
doaj +1 more source
E-Cigarette Liquid Provokes Significant Embryotoxicity and Inhibits Angiogenesis
Toxics, 2020 E-cigarette smoking (ECS) is a new method of tobacco smoking that is gaining popularity as it is thought to be a “healthy method” of tobacco consumption.
Anas A. Ashour +7 more
doaj +1 more source
Apoptosis regulation in adrenocortical carcinoma
Endocrine Connections, 2019 Apoptosis evading is a hallmark of cancer. Tumor cells are characterized by having an impaired apoptosis signaling, a fact that deregulates the balance between cell death and survival, leading to tumor development, invasion and resistance to treatment ...
Sofia S Pereira +3 more
doaj +1 more source
FUS-dependent microRNA deregulations identify TRIB2 as a druggable target for ALS motor neurons
iScience, 2023 Summary: MicroRNAs (miRNAs) modulate mRNA expression, and their deregulation contributes to various diseases including amyotrophic lateral sclerosis (ALS).
Wan Yun Ho +19 more
doaj +1 more source
Frontiers in Immunology, 2021 Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide with rising rates in parallel to obesity, type 2 diabetes, and metabolic syndrome.
Fanhong Zeng +11 more
doaj +1 more source
Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease. [PDF]
PLoS ONE, 2013 Parkinson's disease (PD) is a multifactorial disease known to result from a variety of factors. Although age is the principal risk factor, other etiological mechanisms have been identified, including gene mutations and exposure to toxins. Deregulation of
Pierre O Poliquin +4 more
doaj +1 more source
Democratizing Entry: Banking Deregulations, Financing Constraints, and Entrepreneurship [PDF]
We study how US branch-banking deregulations affected the entry and exit of firms in the non-financial sector using establishment-level data from the US Census Bureau’s Longitudinal Business Database.
William Kerr, Ramana Nanda
core +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular interactions between NAFLD and xenobiotic metabolism
Frontiers in Genetics, 2013 Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, is a complex multifactorial disease characterised by metabolic deregulations that include accumulation of lipids in the liver, lipotoxicity and insulin ...
Adviti eNaik +3 more
doaj +1 more source