Results 81 to 90 of about 641,705 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Inertial-Based Derivative-Free Method for System of Monotone Nonlinear Equations and Application
IEEE Access, 2020 Iterative methods for solving nonlinear problems are of great importance due to their appearance in various areas of applications. In this paper, based on the inertial effect, we propose two projection derivative-free iterative methods for solving system
Aliyu Muhammed Awwal +4 more
doaj +1 more source
An Accelerated Directional Derivative Method for Smooth Stochastic Convex Optimization
, 2020 We consider smooth stochastic convex optimization problems in the context of algorithms which are based on directional derivatives of the objective function.
Dvurechensky, Pavel +2 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Convergence Analysis and Complex Geometry of an Efficient Derivative-Free Iterative Method
Mathematics, 2019 To locate a locally-unique solution of a nonlinear equation, the local convergence analysis of a derivative-free fifth order method is studied in Banach space.
Deepak Kumar +2 more
doaj +1 more source
Derivative-free HS-DY-type method for solving nonlinear equations and image restoration
Heliyon, 2020 A derivative-free conjugate gradient algorithm for solving nonlinear equations and image restoration is proposed. The conjugate gradient (CG) parameter of the proposed algorithm is a convex combination of Hestenes-Stiefel (HS) and Dai-Yuan (DY) type CG ...
Auwal Bala Abubakar +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
On Generalized Composite Fractional Derivative
Walailak Journal of Science and Technology, 2014 In the present paper, we define a generalized composite fractional derivative and obtain results, which include the image of power function, Laplace transform and composition of Riemann-Liouville fractional integral with the generalized composite ...
Mridula GARG +3 more
doaj +1 more source