Results 71 to 80 of about 14,414,832 (247)

Inertial-Based Derivative-Free Method for System of Monotone Nonlinear Equations and Application

IEEE Access, 2020
Iterative methods for solving nonlinear problems are of great importance due to their appearance in various areas of applications. In this paper, based on the inertial effect, we propose two projection derivative-free iterative methods for solving system
Aliyu Muhammed Awwal, Poom Kumam, Lin Wang, Shuang Huang, Wiyada Kumam   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Convergence Analysis and Complex Geometry of an Efficient Derivative-Free Iterative Method

Mathematics, 2019
To locate a locally-unique solution of a nonlinear equation, the local convergence analysis of a derivative-free fifth order method is studied in Banach space.
Deepak Kumar, Janak Raj Sharma, Lorentz Jäntschi   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Derivative free stochastic discrete gradient method with adaptive mutation

, 2006
In data mining we come across many problems such as function optimization problem or parameter estimation problem for classifiers for which a good learning algorithm for searching is very much necessary.
Ranadhir Ghosh, Ghosh, Ranadhir, Ghosh, Moumita, Moumita Ghosh, Adil Bagirov, Bagirov, Adil   +5 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

On the semilocal convergence of derivative free methods for solving nonlinear equations

Journal of Numerical Analysis and Approximation Theory, 2012
We introduce a Derivative Free Method (DFM) for solving nonlinear equations in a Banach space setting. We provide a semilocal convergence analysis for DFM using recurrence relations. Numerical examples validating our theoretical results are also provided
Ioannis K. Argyros, Hongmin Ren
doaj   +2 more sources

On Generalized Composite Fractional Derivative

Walailak Journal of Science and Technology, 2014
In the present paper, we define a generalized composite fractional derivative and obtain results, which include the image of power function, Laplace transform and composition of Riemann-Liouville fractional integral with the generalized composite ...
Mridula GARG, Pratibha MANOHAR, Lata CHANCHALANI, Subhash ALHA   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source