Results 51 to 60 of about 62,722 (247)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Non-parametric free-form optimization of shell structures for reducing the sound pressure in a closed space

Nihon Kikai Gakkai ronbunshu, 2014
This paper describes a parameter-free free-form optimization method for shell structures to reduce the noise in a closed acoustic field. Squared sound pressure, which is evaluated by solving fully coupled shell-acoustic interaction system, is selected as
Masatoshi SHIMODA, Kensuke SHIMOIDE
doaj   +1 more source

Derivative-Free Observability Analysis for Sensor Placement Optimization of Bioinspired Flexible Flapping Wing System

Biomimetics, 2022
Observability analysis of a bioinspired flexible flapping wing system provides a measure of how well the states of flexible flapping wing micro-aerial vehicles can be estimated from real-time measurements during high-speed flight.
Bingyu Jin, Hao Xu, Jicheng Peng, Kelin Lu, Yuping Lu   +4 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

A Second-Order Finite-Difference Method for Derivative-Free Optimization

Journal of Mathematics
In this paper, a second-order finite-difference method is proposed for finding the second-order stationary point of derivative-free nonconvex unconstrained optimization problems.
Qian Chen, Peng Wang, Detong Zhu
doaj   +1 more source

A Direct Search Algorithm for Global Optimization

Algorithms, 2016
A direct search algorithm is proposed for minimizing an arbitrary real valued function. The algorithm uses a new function transformation and three simplex-based operations.
Enrique Baeyens, Alberto Herreros, José R. Perán   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

SpaGrOW—A Derivative-Free Optimization Scheme for Intermolecular Force Field Parameters Based on Sparse Grid Methods

Entropy, 2013
Molecular modeling is an important subdomain in the field of computational modeling, regarding both scientific and industrial applications. This is because computer simulations on a molecular level are a virtuous instrument to study the impact of ...
Dirk Reith, Marco Hülsmann
doaj   +1 more source

The Optimal Shape Parameter for the Least Squares Approximation Based on the Radial Basis Function

Mathematics, 2020
The radial basis function (RBF) is a class of approximation functions commonly used in interpolation and least squares. The RBF is especially suitable for scattered data approximation and high dimensional function approximation.
Sanpeng Zheng, Renzhong Feng, Aitong Huang   +2 more
doaj   +1 more source