Results 121 to 130 of about 3,057,322 (296)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

$Q$-shaped derived categories as derived categories of differential graded bimodules [PDF]

arXiv
We prove that, under mild assumptions, the $Q$-shaped derived categories introduced by Holm and J{\o}rgensen are equivalent to derived categories of differential graded bimodules over differential graded categories. This yields new derived invariance results for $Q$-shaped derived categories that allow us to extend known descriptions of such categories
arxiv  

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The History of -eer in English: Suffix Competition or Symbiosis?

Languages
Ecological models of competition have provided great explanatory power regarding synonymy in derivational morphology. Competition models of this type have certainly shown their utility, as they have demonstrated, among other things, the relevance of ...
Zachary Dukic, Chris C. Palmer
doaj   +1 more source

Linear maps on C*-algebras which are derivations or triple derivations at a point [PDF]

arXiv, 2017
We prove new results on generalized derivations on C$^*$-algebras. By considering the triple product $\{a,b,c\} =2^{-1} (a b^* c + c b^* a)$, we introduce the study of linear maps which are triple derivations or triple homomorphisms at a point. We prove that a continuous linear $T$ map on a unital C$^*$-algebra is a generalized derivation whenever it ...
arxiv  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Research progress of SIRTs activator resveratrol and its derivatives in autoimmune diseases

Frontiers in Immunology
Autoimmune diseases (AID) have emerged as prominent contributors to disability and mortality worldwide, characterized by intricate pathogenic mechanisms involving genetic, environmental, and autoimmune factors.
Xiaolong Yu, Xiaolong Yu, Xiaolong Yu, Mingkai Chen, Jiabiao Wu, Ruixiao Song, Ruixiao Song   +6 more
doaj   +1 more source

Derived tame and derived wild algebras [PDF]

Algebra and Discrete Mathematics, v.3, No.1 (2004) 57-74, 2003
We prove that every finite dimensional algebra over an algebraically closed field is either derived tame or derived wild. We also prove that any deformation of a derived tame algebra is derived tame.
arxiv  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source