Results 201 to 210 of about 3,057,322 (296)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Development and validation of derivative UV spectroscopic methods for simultaneous estimation of duloxetine and tadalafil in their binary mixtures: greenness-blueness evaluation. [PDF]

BMC Chem
Nagy DM, Derayea SM, Zaafan AAS, Oraby M.   +3 more
europepmc   +1 more source

Syntheses of Hydroxy Amino-acid and its N-Methyl Derivatives. III

, 1950
Nobuo Izumiya
openalex   +2 more sources

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Molecular Compounds between Naphthalene, its α-and β-Derivatives and Aromatic Nitro-compounds. I

, 1938
Teiichi ASAHINA, Chiro Shinomiya
openalex   +2 more sources

THE PREPARATION OF 1,4-DIHALOGEN DERIVATIVES OF BUTANE [PDF]

, 1922
C. S. Marvel, A. L. Tanenbaum
openalex   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Analytic solutions of the time-fractional Boiti-Leon-Manna-Pempinelli equation via novel transformation technique. [PDF]

Sci Rep
Yasmeen B, Ahmad K, Akgül A, Al-Mdallal Q.   +3 more
europepmc   +1 more source

THE REACTION OF ACETYLCHOLINE AND OTHER CARBOXYLIC ACID DERIVATIVES WITH HYDROXYLAMINE, AND ITS ANALYTICAL APPLICATION

, 1949
S. Hestrin
openalex   +1 more source

The second derivatives of the extremal-integral [PDF]

, 1908
Arnold Dresden
openalex   +1 more source