Results 71 to 80 of about 3,057,322 (296)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Tame-wild dichotomy for derived categories [PDF]
arXiv, 2003 We prove that every finite dimensional algebra over an algebraically closed field is either derived tame or derived wild. The proof is based on the technique of matrix problems (boxes and reduction algorithm). It implies, in particular, that any degeneration of a derived wild algebra is derived wild; respectively, any deformation of a derived tame ...
arxiv
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Armenian Folia Anglistika, 2019 The paper highlights the most typical features of the lexico-grammatical category of diminutiveness from the derivational point of view. The correlation between language and culture, language and national linguistic traditions, language and national ...
Karine Abrahamyan
doaj +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
The fractional orthogonal derivative
, 2014 This paper builds on the notion of the so-called orthogonal derivative, where an n-th order derivative is approximated by an integral involving an orthogonal polynomial of degree n. This notion was reviewed in great detail in a paper in J. Approx. Theory
Diekema, E.
core +2 more sources
The Dupire derivatives and Fréchet derivatives on continuous pathes [PDF]
arXiv, 2013 In this paper, we study the relation between Fr\'echet derivatives and Dupire derivatives, in which the latter are recently introduced by Dupire [4]. After introducing the definition of Fr\'echet derivatives for non-anticipative functionals, we prove that the Dupire derivatives and the extended Fr\'echet derivatives are coherent on continuous pathes.
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
The derivational family of the noun SAULĖ
Lietuvių Kalba, 2020 The word saulė (‘the sun’) and the denotation indicated by it has a lot of meanings in the Lithuanian culture: the mythologists, philosophers, art critics, and literature critics have written about this phenomenon.
Jolanta Vaskelienė, Greta Girdvilytė
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source