Results 61 to 70 of about 87,489 (268)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Existence and Attractivity of Mild Solutions for Fractional Diffusion Equations Involving the Regularized ψ-Hilfer Fractional Derivatives

Axioms
The regularized ψ-Hilfer derivative within the sense of Caputo is an improved version of the ψ-Hilfer fractional derivative, primarily because it addresses the issue where the initial conditions of problems involving the ψ-Hilfer fractional derivative ...
Luyao Wang, Yuhang Jin, Wenchang He, Jia Mu   +3 more
doaj   +1 more source

An extension of Wolpert’s derivative formula [PDF]

Pacific Journal of Mathematics, 2001
A well known formula, of Wolpert expresses the derivative of length of a geodesic \(\gamma\) on a hyperbolic surface with respect to the Fenchel Nielsen twist about a fixed simple geodesic \(C\) as a sum of the cosines of the intersection angles between the two curves. The author derives an analogous formula for the derivative of the length of \(\gamma\
openaire   +2 more sources

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Existence and Stability for Fractional Differential Equations with a ψ–Hilfer Fractional Derivative in the Caputo Sense

Mathematics
This article aims to explore the existence and stability of solutions to differential equations involving a ψ-Hilfer fractional derivative in the Caputo sense, which, compared to classical ψ-Hilfer fractional derivatives (in the Riemann–Liouville sense),
Wenchang He, Yuhang Jin, Luyao Wang, Ning Cai, Jia Mu   +4 more
doaj   +1 more source

Performance Analyses of Four-Instant Discretization Formulas With Application to Generalized-Sylvester-Type Future Matrix Equation

IEEE Access, 2019
For solving generalized-Sylvester-type future matrix equation (GS-type FME) effectively, the continuous zeroing neural network (ZNN) model should be discretized by appropriate discretization formula.
Zhangqiang Yin, Kang Liu, Yuanhang Chen, Rui Xue, Jian Li, Yang Shi   +5 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A new generalization of Mittag-Leffler function via q-calculus

Advances in Difference Equations, 2020
The present paper deals with a new different generalization of the Mittag-Leffler function through q-calculus. We then investigate its remarkable properties like convergence, recurrence relation, integral representation, q-derivative formula, q-Laplace ...
Raghib Nadeem, Talha Usman, Kottakkaran Sooppy Nisar, Thabet Abdeljawad   +3 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source