Results 41 to 50 of about 272,773 (298)

Contraction-Dependent Apoptosis of Normal Dermal Fibroblasts [PDF]

Journal of Investigative Dermatology, 2001
The mechanisms underlying the contraction-dependent apoptosis of primary fibroblasts are of prime importance in understanding anchorage-dependent survival/apoptosis of dermal fibroblasts. As integrins are essential extracellular matrix receptors in fibroblasts, their role in anchorage-dependent apoptosis/survival of fibroblasts was analyzed.
Niland, Stephan, Cremer, Anja, Fluck, Juliane, Krieg, Thomas, Sollberg, Stephan, Eble, Johannes A.   +5 more
openaire   +2 more sources

Leptin and Pro-Inflammatory Stimuli Synergistically Upregulate MMP-1 and MMP-3 Secretion in Human Gingival Fibroblasts [PDF]

, 2016
Introduction Gingival fibroblast-mediated extracellular matrix remodelling is implicated in the pathogenesis of periodontitis, yet the stimuli that regulate this response are not fully understood. The immunoregulatory adipokine leptin is detectable in
Andrew J Skelton, Todryk, Stephen M., Rowan, Andrew, Skelton, Andrew J., Skelton, Andrew J, Williams, Rachel C., Preshaw, Philip M.; id_orcid, Preshaw, Philip M, Taylor, John, Rowan, Andrew D., Skelton, Andrew, Preshaw, Philip, Taylor, John J, Taylor, John J., Todryk, Stephen, Philip M Preshaw, Todryk, Stephen M, Rachel C Williams, Stephen M Todryk, Williams, Rachel C, Andrew D Rowan, Rowan, Andrew D, John J Taylor   +22 more
core   +2 more sources

The mechano-chemical circuit in fibroblasts and dendritic cells drives basal cell proliferation in psoriasis

Cell Reports
Summary: Psoriasis is an intractable immune-mediated disorder that disrupts the skin barrier. While studies have dissected the mechanism by which immune cells directly regulate epidermal cell proliferation, the involvement of dermal fibroblasts in the ...
Jingwei Jiang, Xinyi Shao, Weiwei Liu, Mengyue Wang, Qiwei Li, Miaomiao Wang, Yang Xiao, Ke Li, Huan Liang, Nian’ou Wang, Xuegang Xu, Yan Wu, Xinghua Gao, Qiaoli Xie, Xiao Xiang, Wanqian Liu, Wang Wu, Li Yang, Zhong-Ze Gu, Jin Chen, Mingxing Lei   +20 more
doaj   +1 more source

Non pharmacological high-intensity ultrasound treatment of human dermal fibroblasts to accelerate wound healing

Scientific Reports, 2021
Inspired by the effectiveness of low-intensity ultrasound on tissue regeneration, we investigated the potential effect of short-term high-intensity ultrasound treatment for acceleration of wound healing in an in vitro wound model and dermal equivalent ...
Jeong Yu Lee, Dae-Jin Min, Wanil Kim, Bum-Ho Bin, Kyuhan Kim, Eun-Gyung Cho   +5 more
doaj   +1 more source

Allogeneic human dermal fibroblasts are viable in peripheral blood mononuclear co-culture [PDF]

Universa Medicina, 2014
Background Transplanted allogeneic dermal fibroblasts retain stem cell subpopulations, and are easily isolated, expanded and stored using standard techniques. Their potential for regenerative therapy of chronic wounds should be evaluated.
Restu Syamsul Hadi, Indra Kusuma, Yurika Sandra   +2 more
doaj   +3 more sources

Decreased susceptibility to Fas-induced apoptosis of systemic sclerosis dermal fibroblasts

, 2001
Objective To determine whether dysregulated apoptosis of systemic sclerosis (SSc) fibroblasts contributes to progressive fibrosis by promoting fibroblast longevity.
Santiago, Begoña, Rivero, Miguel, Galindo Izquierdo, María, Pablos Álvarez, José Luis   +3 more
core   +1 more source

HDAC2 and 7 down-regulation induces senescence in dermal fibroblasts [PDF]

, 2021
Originally simply reported to be in a stable and irreversible growth arrest in vitro, senescent cells are now clearly associated with normal and pathological ageing in vivo. They are characterized by several biomarkers and changes in gene expression that
Piel, Géraldine, Warnon, Céline, Fransolet, Maude, Mottet, Denis, Poumay, Yves, Verhoyen, Mathilde, Lambert de Rouvroit, Catherine, Lambert de Rouvroit, Catherine; id_orcid, Ninane, Noëlle, Fattaccioli, Antoine, Debacq-Chainiaux, Florence, Bouhjar, Karim, Poumay, Yves; id_orcid   +12 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Metformin-stimulated Mannose Transport in Dermal Fibroblasts [PDF]

Journal of Biological Chemistry, 2004
The biguanide drug metformin stimulates AMP-activated protein kinase, a master regulator of cellular energy metabolism, and has antihyperglycemic activity due to attenuation of gluconeogenesis in hepatocytes and 2-fold stimulation of glucose transport by skeletal muscle.
Jie, Shang, Mark A, Lehrman
openaire   +2 more sources

Hair follicle dermal cells: a morphological, behavioural and molecular study [PDF]

, 1995
Anatomy and smooth muscle a-actin expression in hair follicles from a variety of animal species (Mink, Polecat, Meerkat, Grey squirrel and stoat) was investigated. Smooth muscle ɑ-actin expression was related to follicle activity. Expression was greatest
Sleeman, Matthew Alexander, Sleeman, M
core