Results 31 to 40 of about 272,773 (298)

Advances in Skin Substitutes—Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing

Journal of Functional Biomaterials, 2015
Skin protects the body from exogenous substances and functions as a barrier to fluid loss and trauma. The skin comprises of epidermal, dermal and hypodermal layers, which mainly contain keratinocytes, fibroblasts and adipocytes, respectively, typically ...
Mathew Varkey, Jie Ding, Edward E. Tredget   +2 more
doaj   +1 more source

Microporous dermal-mimetic electrospun scaffolds pre-seeded with fibroblasts promote tissue regeneration in full-thickness skin wounds. [PDF]

PLoS ONE, 2015
Electrospun scaffolds serve as promising substrates for tissue repair due to their nanofibrous architecture and amenability to tailoring of chemical composition.
Paul P Bonvallet, Matthew J Schultz, Elizabeth H Mitchell, Jennifer L Bain, Bonnie K Culpepper, Steven J Thomas, Susan L Bellis   +6 more
doaj   +1 more source

Human Dermal Fibroblasts Synthesize Laminin

Journal of Investigative Dermatology, 1988
Laminin, a glycoprotein of approximately 900,000 daltons, is a major component of the basement membrane that separates the epidermis from dermis in human skin. Previous studies have shown that keratinocytes and other epithelial cells synthesize laminin and utilize it for attachment to other extracellular matrices such as heparan sulfate proteoglycan ...
Woodley, David T., Stanley, John R., Reese, Melinda J., O'keefe, Edward J.   +3 more
openaire   +2 more sources

Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.

PLoS ONE, 2015
In stem cell cultures from adult human tissue, undesirable contamination with fibroblasts is frequently present. The presence of fibroblasts obscures the actual number of stem cells and may result in extracellular matrix production after transplantation.
C J Janmaat, K E de Rooij, H Locher, S C de Groot, J C M J de Groot, J H M Frijns, M A Huisman   +6 more
doaj   +1 more source

18ß-glycyrrhetinic acid derivative promotes proliferation, migration and aquaporin-3 expression in human dermal fibroblasts. [PDF]

PLoS ONE, 2017
Licorice (Glycyrrhiza) species have been widely used as a traditional medicine and a natural sweetener in foods. The 18β-glycyrrhetinic acid (18β-GA) is a bioactive compound in licorice that exhibits potential anti-cancer, anti-inflammatory, and anti ...
Chi-Feng Hung, Chien-Yu Hsiao, Wen-Hao Hsieh, Hsin-Ju Li, Yi-Ju Tsai, Chun-Nan Lin, Hsun-Hsien Chang, Nan-Lin Wu   +7 more
doaj   +1 more source

Improved Dermal Regeneration Using a Combination of Dermal Substitutes and Dermal Fibroblast Optimization: A Hypothesis [PDF]

Medical Science Monitor, 2018
In human adults, the repair of cutaneous wounds usually leads to scar formation rather than regeneration. Dermal substitutes have been used as a regenerative template for reducing scar formation and improving the extent of dermal regeneration. However, achievement of complete regeneration is still a long way off. Dermal substitutes are characterized by
Shi, Haifei, Weng, Tingting, Han, Chunmao, Wang, Xingang   +3 more
openaire   +2 more sources

Tissue and Isoform-Specific Effects of Platelet-Derived Growth Factor on Neonatal-Derived Dermal and Fetal-Derived Lung Fibroblast Profibrotic Functions

Cells
Elevated levels of platelet-derived growth factor (PDGF) isoforms in fibrosis are implicated in driving a dysfunctional profibrotic fibroblast phenotype.
Brandon Kohlen, Raveen Badyal, Kevin J. Keen, James V. Dunne, Tillie-Louise Hackett   +4 more
doaj   +1 more source

LncRNA ST6GALNAC3 inhibits dermal fibroblast proliferation and migration in cashmere goat hair follicles via the chi-miR-24-3p/ID4 axis [PDF]

Animal Bioscience
Objective Dermal papilla is developed from the continuous proliferation and differentiation of dermal fibroblasts, which is the key to the normal development of hair follicles.
Rong Ma, Qing Ma, Lu Zhang, Bingjie Ma, Xuxu Bao, Yiming Zhang, Le Wang, Qi Lv, Zhiying Wang, Ruijun Wang, Rui Su, Yanhong Zhao, Fangzheng Shang, Yu Wang, Yanjun Zhang   +14 more
doaj   +1 more source

Interleukin-1β attenuates myofibroblast formation and extracellular matrix production in dermal and lung fibroblasts exposed to transforming growth factor-β1. [PDF]

PLoS ONE, 2014
One of the most potent pro-fibrotic cytokines is transforming growth factor (TGFβ). TGFβ is involved in the activation of fibroblasts into myofibroblasts, resulting in the hallmark of fibrosis: the pathological accumulation of collagen.
Masum M Mia, Miriam Boersema, Ruud A Bank   +2 more
doaj   +1 more source

3D Cell Migration Studies for Chemotaxis on Microfluidic-Based Chips: A Comparison between Cardiac and Dermal Fibroblasts

Bioengineering, 2018
Fibroblast migration to damaged zones in different tissues is crucial to regenerate and recuperate their functional activity. However, fibroblast migration patterns have hardly been studied in disease terms.
Sandra Pérez-Rodríguez, Esther Tomás-González, José Manuel García-Aznar   +2 more
doaj   +1 more source