Results 11 to 20 of about 272,773 (298)

Influence of Human Dermal Fibroblasts on Epidermalization [PDF]

Journal of Investigative Dermatology, 1989
Using a method that allowed the reconstruction of simplified living human skin in vitro, we investigated the effects of collagen texture and dermal fibroblasts on epidermal growth. Like in vivo skin, our in vitro model comprised two tissues: a dermal equivalent and an overlying epidermis.
Coulomb, Bernard, Lebreton, Corinne, Dubertret, Louis   +2 more
openaire   +3 more sources

Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules. [PDF]

PLoS ONE, 2017
Gamma-glutamyl carboxylase (GGCX) gene mutation causes GGCX syndrome (OMIM: 137167), which is characterized by pseudoxanthoma elasticum (PXE)-like symptoms and coagulation impairment.
Yumi Okubo, Ritsuko Masuyama, Akira Iwanaga, Yuta Koike, Yutaka Kuwatsuka, Tomoo Ogi, Yosuke Yamamoto, Yuichiro Endo, Hiroshi Tamura, Atsushi Utani   +9 more
doaj   +3 more sources

Isolation and Culture of Human Dermal Fibroblasts

, 2019
Dermal fibroblasts are the main cell type present in skin connective tissue (dermis). Fibroblasts interact with epidermal cells during hair development and in interfollicular skin. Moreover, they play an essential role during cutaneous wound healing and in bioengineering of skin. Hence, culture of primary fibroblast is gaining in importance.
Kisiel MA, Klar AS
openaire   +4 more sources

Impact of Human Dermal Microvascular Endothelial Cells on Primary Dermal Fibroblasts in Response to Inflammatory Stress [PDF]

Frontiers in Cell and Developmental Biology, 2019
The aim of the present study was to evaluate the impact of the microenvironment produced by dermal microvascular endothelial cells, secondary to a pro-inflammatory challenge, on 2D culture models using dermal fibroblasts and in 3D reconstructed skin ...
Benjamin Sanchez, Benjamin Sanchez, Linan Li, Joshua Dulong, Joshua Dulong, Géraldine Aimond, Géraldine Aimond, Jérôme Lamartine, Jérôme Lamartine, Guangrong Liu, Dominique Sigaudo-Roussel, Dominique Sigaudo-Roussel   +11 more
doaj   +2 more sources

Defining the identity of mouse embryonic dermal fibroblasts [PDF]

genesis, 2016
SummaryEmbryonic dermal fibroblasts in the skin have the exceptional ability to initiate hair follicle morphogenesis and contribute to scarless wound healing. Activation of the Wnt signaling pathway is critical for dermal fibroblast fate selection and hair follicle induction.
Budnick, Isadore, Hamburg-Shields, Emily, Chen, Demeng, Torre, Eduardo, Jarrell, Andrew, Akhtar-Zaidi, Batool, Cordovan, Olivia, Spitale, Rob C, Scacheri, Peter, Atit, Radhika P   +9 more
openaire   +6 more sources

Dermal Fibroblasts Promote the Migration of Dendritic Cells [PDF]

Journal of Investigative Dermatology, 2010
Migration of dendritic cells (DCs) from skin to lymph nodes on activation is an essential step in the initiation of an adequate immune response. The dermal microenvironment including stromal cells and their soluble factors might be involved in the regulation of DC migration.
Saalbach, Anja, Klein, Claudia, Schirmer, Christine, Briest, Wilfried, Anderegg, Ulf, Simon, Jan C.   +5 more
openaire   +4 more sources

The weakness of senescent dermal fibroblasts

Proceedings of the National Academy of Sciences, 2023
Skin is the largest human organ with easily noticeable biophysical manifestations of aging. As human tissues age, there is chronological accumulation of biophysical changes due to internal and environmental factors. Skin aging leads to decreased elasticity and the loss of dermal matrix integrity via degradation.
Lydia Rebehn, Samira Khalaji, Fenneke KleinJan, Anja Kleemann, Fabian Port, Patrick Paul, Constantin Huster, Ulla Nolte, Karmveer Singh, Lisa Kwapich, Jonas Pfeil, Taner Pula, Pamela Fischer-Posovszky, Karin Scharffetter-Kochanek, Kay-E. Gottschalk   +14 more
openaire   +2 more sources

Sphingolipids control dermal fibroblast heterogeneity

Science, 2022
Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition. Here, we measured the lipidomes and transcriptomes of individual human dermal fibroblasts by coupling ...
Laura Capolupo, Irina Khven, Alex R. Lederer, Luigi Mazzeo, Galina Glousker, Sylvia Ho, Francesco Russo, Jonathan Paz Montoya, Dhaka R. Bhandari, Andrew P. Bowman, Shane R. Ellis, Romain Guiet, Olivier Burri, Johanna Detzner, Johannes Muthing, Krisztian Homicsko, François Kuonen, Michel Gilliet, Bernhard Spengler, Ron M. A. Heeren, G. Paolo Dotto, Gioele La Manno, Giovanni D’Angelo   +22 more
openaire   +5 more sources

Enhancement Of Dermal Fibroblast Isolation Method [PDF]

Serbian Journal of Experimental and Clinical Research, 2015
ABSTRACT Cultivated fibroblasts have been widely used in a large number of in vitro studies. Although they readily proliferate under cell culture conditions, improvements in methods for their isolation are necessary. Here, we present our modified enzyme digestion method and compare its efficiency with commonly used techniques.
Zaric, Milan, Nikolic I., Zelen I., Mitrovic M., Milosavljevic Z.   +4 more
openaire   +2 more sources

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +2 more sources