Results 1 to 10 of about 67,632 (263)
The role of sirtuins in dermal fibroblast function
Frontiers in Medicine, 2023 The sirtuins are a family of seven proteins that perform a variety of dermatological functions and help maintain both the structure and function of the skin.
Michael M. Gilbert +10 more
doaj +3 more sources
Microbiology Spectrum, 2023 Four serotypes of dengue virus (DENV-1 to DENV-4) cause mild to severe disease in humans through infected mosquito bites. Dermal fibroblasts were found to be susceptible to DENV, and this may play a critical role in establishing the initial infection ...
Kai-Che Wei +2 more
exaly +3 more sources
α-Ionone Protects Against UVB-Induced Photoaging in Human Dermal Fibroblasts
Molecules, 2019 Ultraviolet (UV) light-induced wrinkle formation is a major dermatological problem and is associated with alteration in collagen. Here, we investigated the potential of α-ionone, a naturally occurring aromatic compound, in regulation of UVB-induced ...
Wesuk Kang, Jinju Park, Tao Tong
exaly +3 more sources
Scientific Reports, 2023 Phosphodiesterase (PDE) 4 inhibitors have been reported to suppress the progression of dermal fibrosis in patients with systemic sclerosis (SSc); however, the precise mechanisms remain to be elucidated. Therefore, we conducted experiments focusing on the
Tomoaki Higuchi +8 more
doaj +1 more source
Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? [PDF]
PLoS ONE, 2011 Unlike skin, oral gingiva do not scar in response to injury. The basis of this difference is likely to be revealed by comparing the responses of dermal and gingival fibroblasts to fibrogenic stimuli.
Fen Guo +3 more
doaj +1 more source
Scientific Reports, 2023 Systemic Sclerosis (SSc) hallmark is skin fibrosis, but up to 80% of the patients have fibrotic involvement in the pulmonary system. Antifibrotic drugs which have failed in a general SSc population have now been approved in patients with SSc-associated ...
Sofie Falkenløve Madsen +6 more
doaj +1 more source
Puerarin blocks the aging phenotype in human dermal fibroblasts.
PLoS ONE, 2021 Dermal fibroblast aging contributes to aging-associated functional defects in the skin since dermal fibroblasts maintain skin homeostasis by interacting with the epidermis and extracellular matrix.
Yuki Kamiya +4 more
doaj +1 more source
MicroRNA 181b regulates decorin production by dermal fibroblasts and may be a potential therapy for hypertrophic scar. [PDF]
PLoS ONE, 2015 Hypertrophic scarring is a frequent fibroproliferative complication following deep dermal burns leading to impaired function and lifelong disfigurement. Decorin reduces fibrosis and induces regeneration in many tissues, and is significantly downregulated
Peter Kwan, Jie Ding, Edward E Tredget
doaj +1 more source
Cells, 2021 The dermis is the connective layer between the epidermis and subcutis and harbours nerve endings, glands, blood vessels, and hair follicles. The most abundant cell type is the fibroblast.
Kimberly Nickel +4 more
doaj +1 more source
Key regulatory role of dermal fibroblasts in pigmentation as demonstrated using a reconstructed skin model: impact of photo-aging. [PDF]
PLoS ONE, 2014 To study cutaneous pigmentation in a physiological context, we have previously developed a functional pigmented reconstructed skin model composed of a melanocyte-containing epidermis grown on a dermal equivalent comprising living fibroblasts. The present
Christine Duval +5 more
doaj +1 more source