Results 81 to 90 of about 412,458 (245)

Prolonged IL‐33 Exposure Switches the Secreted Mast Cell Cytokine Profile From Pro‐Inflammatory to Pro‐Tolerant

Allergy, EarlyView.
This study investigates the effect of IL‐33 and Hymenoptera venom on mast cell cytokine profiles under venom immunotherapy (VIT)‐like conditions. Our in vitro model of VIT‐like mast cell stimulation demonstrates a modulatory effect of IL‐33 on the secreted mast cell cytokine profile.
Andrea R. Teufelberger, Carolin Költgen, Magda Babina, Peter Wolf   +3 more
wiley   +1 more source

Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction

Einstein (São Paulo), 2019
The fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is ...
Amanda Rocha Firmino Pereira, Marcelo Vivolo Aun, Nathália Coelho Portilho Kelmann, Antônio Abílio Motta, Jorge Kalil, Pedro Giavina-Bianchi   +5 more
doaj   +2 more sources

Outcome of recipients of human leukocyte antigen incompatible kidney transplants who underwent desensitization at King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Saudi Journal of Kidney Diseases and Transplantation, 2017
In patients whom are highly sensitized immunologically, the benefit of kidney transplantation can be extended to this population through the utilization of organs from human leukocyte antigen incompatible (HLAi) donors.
Mohammed Abdulrahim Idris, A. Hossain, Mohammed Abdulrahman Muntasir, Adnan Marmi, A. A. Aldajani, Y. Aljamaan, M. Akhtar, A. Housawi   +7 more
semanticscholar   +1 more source

Decreased Severity of Oral Immunotherapy Induced Gastrointestinal Eosinophilic Reactions Following Revisions in Milk‐Treatment Protocol

Allergy, EarlyView.
A revised milk OIT protocol with lower daily allergen load and slower dose escalation reduced the severity and delayed onset of OIT‐induced gastrointestinal eosinophilic reactions (OITIGER). Elevated baseline absolute eosinophil count (AEC > 600/μL) was a consistent independent risk factor for OITIGER, while older age was protective.
Na'ama Epstein‐Rigbi, Matan Elkan, Yair Tzarfati, Michael B. Levy, Liat Nachshon, Yael Koren, Yitzhak Katz, Arnon Elizur, Michael R. Goldberg   +8 more
wiley   +1 more source

HLA Mismatching Strategies for Solid Organ Transplantation - a Balancing Act

Frontiers in Immunology, 2016
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression.
Andrea A. Zachary, Mary S Leffell
doaj   +1 more source

Psoriasis—An Immunological Disease [PDF]

, 1996
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111129/1/jde02714 ...
Alroy, Baadsgaard, Bach, Bata-Csorgo, Berg, Cronstein, Ellis, Enk, Gandangi, Griffiths, Griffiths, Halprin, Hammarstrom, Judge, Menssen, Morganroth, Mueller, Nesde, Rivas, Robinson, Scheinman, Schlaak, Uyemura, Valdimarsson, Voorhees, Voorhees, Weinstein   +26 more
core   +1 more source

Desensitization for solid organ and hematopoietic stem cell transplantation

Immunological Reviews, 2014
Desensitization protocols are being used worldwide to enable kidney transplantation across immunologic barriers, i.e. antibody to donor HLA or ABO antigens, which were once thought to be absolute contraindications to transplantation.
A. Zachary, M. Leffell
semanticscholar   +1 more source

Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen‐Specific Immune Responses

Allergy, EarlyView.
We used PBMC transcriptome from 50 hen's egg‐allergic patients to study the role of lncRNA in OIT. Positive correlation was found between 17 lncRNAs and the IL‐4/IL‐13 pathway in vivo, and the expression of the selected lncRNA aligned with CXCL8 upon PBMC egg‐restimulation.
Olivia Liong, Kati Palosuo, Victoria Hinkkanen, Vittorio Fortino, Mika J. Mäkelä, Piia Karisola   +5 more
wiley   +1 more source

Efficacy and safety of a house dust mites allergoid in patients with allergic rhinitis—PROACAROS study: protocol for a randomized controlled trial

Trials
Background There is an important heterogeneity of the clinical research done to date for allergen immunotherapy (AIT). We plan to assess the safety and efficacy of a house dust mite (HDM) polymerized allergen extract mixture for allergic ...
Inmaculada Buendía-Jiménez, María Matas-Ros, Teresa Garriga-Baraut, Albert Roger-Reig, Ana Tabar-Purroy, on behalf of the PROACAROS investigator group   +5 more
doaj   +1 more source

Skin as an immune organ and clinical applications of skin-based immunotherapy

World Allergy Organization Journal, 2018
Background The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food allergy as well as other allergic ...
J. Andrew Bird, Mario Sánchez-Borges, Ignacio J. Ansotegui, Motohiro Ebisawa, José Antonio Ortega Martell   +4 more
doaj   +1 more source