Results 81 to 90 of about 467,831 (278)

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, EarlyView.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction

open access: yesEinstein (São Paulo), 2019
The fixed drug eruption is a non-immediate hypersensitivity reaction to drug, characterized by recurrent erythematous or violaceous, rounded, well-defined border plaques, which always appear in the same location every time the culprit drug is ...
Amanda Rocha Firmino Pereira   +5 more
doaj   +2 more sources

Immediate and delayed hypersensitivity reactions to a single dose of oxaliplatin [PDF]

open access: yes, 2015
Hypersensitivity reaction (HSR), occurring during or immediately after oxaliplatin infusions are well documented and occur more commonly after multiple courses of therapy.A 69-year-old white woman with Stage Ill colon cancer commenced adjuvant ...
Badrick, Timothy C.   +2 more
core   +1 more source

Cellular Mechanism and Key Insights in Allergen Immunotherapy for Allergic Rhinitis

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Allergic rhinitis (AR) arises from immune responses mediated by immunoglobulin E (IgE) to inhaled allergens, representing one of the most prevalent chronic conditions worldwide. Although AR may not be a serious ailment, it holds clinical relevance as it underpins numerous complications, serves as a major risk factor for suboptimal asthma ...
Zhe Wang   +3 more
wiley   +1 more source

Efficacy and safety of a house dust mites allergoid in patients with allergic rhinitis—PROACAROS study: protocol for a randomized controlled trial

open access: yesTrials
Background There is an important heterogeneity of the clinical research done to date for allergen immunotherapy (AIT). We plan to assess the safety and efficacy of a house dust mite (HDM) polymerized allergen extract mixture for allergic ...
Inmaculada Buendía-Jiménez   +5 more
doaj   +1 more source

HLA Mismatching Strategies for Solid Organ Transplantation - a Balancing Act

open access: yesFrontiers in Immunology, 2016
HLA matching provides numerous benefits in organ transplantation including better graft function, fewer rejection episodes, longer graft survival, and the possibility of reduced immunosuppression.
Andrea A. Zachary, Mary S Leffell
doaj   +1 more source

Association between malaria exposure and Kaposi's sarcoma-associated herpes virus seropositivity in Uganda. [PDF]

open access: yes, 2015
OBJECTIVE: Unlike other herpes viruses, Kaposi's sarcoma-associated herpes virus (KSHV) is not ubiquitous worldwide and is most prevalent in sub-Saharan Africa. The reasons for this are unclear. As part of a wider investigation of factors that facilitate
Cose, Stephen   +8 more
core   +2 more sources

Dupilumab‐Related Adverse Events and Intolerance in Aspirin‐Exacerbated Respiratory Disease Patients

open access: yes
International Forum of Allergy &Rhinology, EarlyView.
Lancelot P. Herpin   +8 more
wiley   +1 more source

Peanut Component‐Specific IgE and IgG4 Are Modulated by Sublingual Immunotherapy and Are Associated With Remission in 1–4‐Year‐Old Children

open access: yesAllergy, EarlyView.
This study presents a post hoc analysis of longitudinal changes in peanut component‐specific IgE and IgG4 in children aged 1–4 years undergoing peanut SLIT, aiming to uncover immune mechanisms and potential biomarkers of remission. Peanut SLIT reduced IgE and increased IgG4 responses to Ara h 1, Ara h 2, Ara h 3, and Ara h 6.
Neel Singh   +9 more
wiley   +1 more source

Skin as an immune organ and clinical applications of skin-based immunotherapy

open access: yesWorld Allergy Organization Journal, 2018
Background The prevalence of food allergy is increasing, and allergen avoidance continues to be the main standard of care. There is a critical need for safe and effective forms of immunotherapy for patients with food allergy as well as other allergic ...
J. Andrew Bird   +4 more
doaj   +1 more source

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