Results 31 to 40 of about 158,350 (323)

Mechanisms of synaptic depression at the hair cell ribbon synapse that support auditory nerve function [PDF]

, 2017
Inner hair cells (IHCs) in the cochlea are the mammalian phono-receptors, transducing sound energy into graded changes in membrane potentials, the so called “receptor potentials.” Ribbon synapses between IHCs and auditory nerve neurons are responsible ...
Goutman, Juan Diego
core   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
core   +3 more sources

Platinum desensitization therapy and its impact on the prognosis of ovary high-grade serous adenocarcinoma: a real world-data

Frontiers in Immunology
BackgroundTo examine the value of five-step platinum desensitization therapy in epithelial ovarian cancerMethodsA retrospective study was conducted on the high-grade serous adenocarcinoma of the ovary (HGSAO) patients who developed a platinum allergy ...
Kemin Li, Kemin Li, Rutie Yin, Rutie Yin
doaj   +1 more source

B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization

Frontiers in Medicine, 2021
Background: Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR).
David Cucchiari, David Cucchiari, Valeria Tubita, Jordi Rovira, Jordi Rovira, Maria J. Ramirez-Bajo, Maria J. Ramirez-Bajo, Elisenda Banon-Maneus, Elisenda Banon-Maneus, Marta Lazo-Rodriguez, Natalia Hierro-Garcia, Francesc E. Borràs, Francesc E. Borràs, Francesc E. Borràs, Pedro Ventura-Aguiar, Gastón J. Piñeiro, Jaume Martorell, Lluís Peri, Mireia Musquera, Alexandre Hertig, Federico Oppenheimer, Federico Oppenheimer, Josep M. Campistol, Josep M. Campistol, Josep M. Campistol, Fritz Diekmann, Fritz Diekmann, Fritz Diekmann, Ignacio Revuelta, Ignacio Revuelta, Ignacio Revuelta   +30 more
doaj   +1 more source

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa, Lopez-Gimenez, Juan, Milligan, Graeme   +2 more
core   +1 more source

The role of cardiac troponin T quantity and function in cardiac development and dilated cardiomyopathy [PDF]

, 2008
Background: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies results from sarcomeric protein mutations, including cardiac troponin T (cTnT, TNNT2).
Ahmad, F, Banerjee, SK, Conner, DA, Huang, XN, Janczewski, AM, Keller, BB, Lage, ML, Mathier, MA, Moskowitz, IP, Perez-Atayde, AR, Rager, J, Saba, S, Seidman, CE, Seidman, JG, Shroff, SG, Smith, SH, Tinney, JP, Tobita, K   +17 more
core   +4 more sources

Threonine 180 Is Required for G-protein-coupled Receptor Kinase 3- and β-Arrestin 2-mediated Desensitization of the µ-Opioid Receptor in Xenopus Oocytes [PDF]

, 2001
To determine the sites in the µ-opioid receptor (MOR) critical for agonist-dependent desensitization, we constructed and coexpressed MORs lacking potential phosphorylation sites along with G-protein activated inwardly rectifying potassium channels ...
Celvert, Jeremy P., Chavkin, Charles, Gurevich, Vsevolod V., Kovoor, Abraham, Lowe, Janet   +4 more
core  

Near‐Infrared Organic Photovoltaic Electrodes for Subretinal Neurostimulation

Advanced Functional Materials, EarlyView.
Organic photovoltaic electrodes based on the D18:Y6 blend enable precise and light‐controlled activation of retinal ganglion cells in a degenerating retina. NIR Light‐driven activation of retinal ganglion cells, tunable stimulation parameters, and biocompatibility with human retinal organoids highlight their potential for next‐generation prosthetics ...
Andrea Corna, Katarina Gugujonovic, Manuela Schiek, Alessandro Bellapianta, Paul Werginz, Amelie Ziller, Markus Clark Scharber, Ahmad Salti, Matthias Bolz, Mihai Irimia‐Vladu, Günther Zeck   +10 more
wiley   +1 more source

PERBEDAAN KEMAMPUAN PASTA GIGI DESENSITISASI KOMERSIAL DENGAN BAHAN AKTIF HIDROKSIAPATIT DAN NOVAMIN DALAM PENUTUPAN TUBULUS DENTIN DENGAN SCANNING ELECTRON MICROSCOPE

ODONTO: Dental Journal, 2016
Background: The use of commercial desensitization toothpaste is one of the way to treat dentine hypersensitivity. Desensitization tooth paste contains an active ingredient which is able to occlude the dentinal tubules to minimize the movement of fluid in
Hardita Bicevani Mulya, Andina Rizkia Putri Kusuma, Aning susilowati   +2 more
doaj   +1 more source

The desensitization gating of the MthK K+ channel is governed by its cytoplasmic amino terminus. [PDF]

PLoS Biology, 2008
The RCK-containing MthK channel undergoes two inactivation processes: activation-coupled desensitization and acid-induced inactivation. The acid inactivation is mediated by the C-terminal RCK domain assembly.
Mario Meng-Chiang Kuo, Innokentiy Maslennikov, Brent Molden, Senyon Choe   +3 more
doaj   +1 more source