Results 41 to 50 of about 18,140 (98)

A valve-like mechanism controls desensitization of functional mammalian isoforms of acid-sensing ion channels

open access: yeseLife, 2019
ASICs are proton-gated sodium channels expressed in neurons. Structures of chicken ASIC1 in three conformations have advanced understanding of proton-mediated gating; however, a molecular mechanism describing desensitization from open and pre-open states
Yangyu Wu   +2 more
doaj   +1 more source

Intrauterine desensitization enables long term survival of human oligodendrocyte progenitor cells without immunosuppression

open access: yesiScience, 2023
Summary: Immune rejection can be reduced using immunosuppressants which are not viable for premature infants. However, desensitization can induce immune tolerance for premature infants because of underdeveloped immune system.
Dou Ye   +14 more
doaj  

Effects of anti-HLA donor-specific antibodies and desensitization on engraftment of haploidentical hematopoietic stem cell transplantation

open access: yes陆军军医大学学报
Objective To investigate the effects of anti-HLA donor-specific antibodies (DSA) and desensitization for DSA+patients on engraftment of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Methods The patients who underwent haplo-HSCT and
MA Yao, ZHANG Yanfang, ZHOU Kang
doaj   +1 more source

Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

open access: yeseLife, 2015
AMPA receptor (AMPAR) function is modulated by auxiliary subunits. Here, we report on three AMPAR interacting proteins—namely CKAMP39, CKAMP52 and CKAMP59—that, together with the previously characterized CKAMP44, constitute a novel family of auxiliary ...
Paul Farrow   +7 more
doaj   +1 more source

Aspirin Desensitization and Percutaneous Coronary Intervention in a Patient with Aspirin Hypersensitivity and Acute Coronary Syndrome: A Case Report

open access: yesJournal of Nepal Medical Association
Hypersensitivity to aspirin is rare disorder occurring in 1.88% of the patients. Aspirin-hypersensitive patients requiring single antiplatelet agent may be treated with clopidogrel, an alternative antiplatelet agent.
Suman Acharya   +7 more
doaj   +1 more source

Desensitization in patients with hypersensitivity to platinum and taxane in gynecological cancers

open access: yesCancer Medicine
Background Exposure to paclitaxel and carboplatin has the risk of developing hypersensitivity reactions (HSRs), which could necessitate using less effective treatments to avoid anaphylaxis.
Tibor A. Zwimpfer   +6 more
doaj   +1 more source

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