Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
An integrated expert weight determination method for design concept evaluation. [PDF]
Sci Rep, 2022 Chen Z, Zhong P, Liu M, Ma Q, Si G.
europepmc +1 more source
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Influence of a new abutment design concept on the biomechanics of peri-implant bone, implant components, and microgap formation: a finite element analysis. [PDF]
BMC Oral Health, 2023 Nie H +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
AI-Assisted Design Concept Exploration Through Character Space Construction. [PDF]
Front Psychol, 2021 Sano S, Yamada S.
europepmc +1 more source
Multi-objective robust concept exploration within the made-to-order sector [PDF]
, 1999 Concept exploration is an activity of fundamental importance when designing large, complex made-to-order engineering products. At the concept design stage of the design process, it is essential that many design alternatives are evaluated.
Coates, Graham +2 more
core
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Creative vs Defective: A Critical Review of Malang Creative Center (MCC) in Malang City
RUASThe Malang Creative Center (MCC) construction is a step taken by the Malang City government to support the flow of modernization and as a forum for Malang residents to develop their creativity. The MCC display concept is planned by combining the shape of
Bunga Pasadena Ineru +4 more
doaj +1 more source