Results 101 to 110 of about 5,666,479 (292)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Perspectives on the role of materials in sustainable product design education
Temes de Disseny, 2018 This paper discusses present and future roles of materials in sustainable design with a focus on design education. With a multifaceted understanding of materials, from an educational perspective, the challenge is to ensure that students are able to ...
Karen Marie Hasling
doaj +1 more source
The influence of national policies on the evolution of industrial design education in China. [PDF]
Heliyon, 2023 Li S, Zhang Y, Wang Z, Li H.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cubic Journal, 2021 This paper provides an argument against understanding risk-taking in design education as something ideally in need of only being calculable and formalisable.
Bo Allesøe Christensen +2 more
doaj
An importance-performance analysis of teachers' perception of STEM engineering design education. [PDF]
Humanit Soc Sci Commun, 2023 Chien YH, Chang FY.
europepmc +1 more source
Creativity in Mass-Education Contexts [PDF]
, 2006 This paper discusses a learning framework (working title: ‘fog framework’) that has been developed in response to the challenge of teaching creative subjects in a mass-education context.
Anusas, M.
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Insights into product design students' perception of, and engagement with, creativity in design education. [PDF]
Int J Technol Des Educ, 2023 McInerney D.
europepmc +1 more source
Education Software Design of Faculty Room for Energy Efficiency [PDF]
, 2015 Nowadays, Global Warming has become a new issue whom impact can be very devastating and can threat the earth and human existence in the future. Since the impact can be very dangerous, many efforts have been done and many ideas have been proposed to ...
Isnanda, R. G. (Reza)
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