Results 1 to 10 of about 17,265,464 (329)
Optimal Monitoring Design [PDF]
Econometrica, 2020 This paper considers a Principal–Agent model with hidden action in which the Principal can monitor the Agent by acquiring independent signals conditional on effort at a constant marginal cost. The Principal aims to implement a target effort level at minimal cost. The main result of the paper is that the optimal information‐acquisition strategy is a two‐
Georgiadis, George, Szentes, Balázs
openaire +2 more sources
Advances in Cryochemistry: Mechanisms, Reactions and Applications
Molecules, 2021 It is counterintuitive that chemical reactions can be accelerated by freezing, but this amazing phenomenon was discovered as early as the 1960s. In frozen systems, the increase in reaction rate is caused by various mechanisms and the freeze concentration
Lu-Yan An, Zhen Dai, Bin Di, Li-Li Xu
doaj +1 more source
Recent Advancements in Design Optimization of Lattice‐Structured Materials
Advanced Engineering Materials, 2023 Metamaterials, also known as lattice‐structured materials, imitate the multifunctionality of natural architects as tailoring their physical properties is associated with manipulating their microstructure. As the recent evolution of additive manufacturing
Abdulla Almesmari +4 more
semanticscholar +1 more source
Angiogenic signaling pathways and anti-angiogenic therapy for cancer
Signal Transduction and Targeted Therapy, 2023 Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- and anti-angiogenic molecules, which plays a crucial role in tumor growth, invasion, and metastasis.
Zhen-Ling Liu +4 more
doaj +1 more source
Scarce Sample-Based Reliability Estimation and Optimization Using Importance Sampling
Mathematical and Computational Applications, 2022 Importance sampling is a variance reduction technique that is used to improve the efficiency of Monte Carlo estimation. Importance sampling uses the trick of sampling from a distribution, which is located around the zone of interest of the primary ...
Kiran Pannerselvam +2 more
doaj +1 more source
Nature Communications, 2022 The kinase DYRK2 is a known oncogene but its role in prostate cancer is unexplored. Here, the authors identify DYRK2 as a target for prostate cancer with a role in invasion and they discover a specific DYRK2 inhibitor that has good pharmacokinetics and ...
Kai Yuan +17 more
doaj +1 more source
Cell Death and Disease, 2021 Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repression of the oncogenic transcription factor FOXM1
Shu-Ping Wang +7 more
doaj +1 more source
Noise prediction research of a scaled turboprop aircraft
Xibei Gongye Daxue Xuebao, 2021 Aerodynamic noise level has become an important performance index of civil aircraft, and it is drawing more and more attention. Most airframe noise research based on CFD method is aimed at aircraft individual parts at present, while lack of noise ...
Song Minhua +5 more
doaj +1 more source
SSRN Electronic Journal, 2010 This paper introduces three methodological advances to study the optimal design of static and dynamic markets. First, we apply a mechanism design approach to characterize all incentive-compatible market equilibria. Second, we conduct a normative analysis, i.e. we evaluate alternative competition and innovation policies from a welfare perspective. Third,
Boone, Jan, Goeree, Jacob K
openaire +6 more sources
Data-Informed Decomposition for Localized Uncertainty Quantification of Dynamical Systems
Vibration, 2020 Industrial dynamical systems often exhibit multi-scale responses due to material heterogeneity and complex operation conditions. The smallest length-scale of the systems dynamics controls the numerical resolution required to resolve the embedded physics.
Waad Subber +4 more
doaj +1 more source