Results 41 to 50 of about 17,265,464 (329)

BKM120 sensitizes BRCA-proficient triple negative breast cancer cells to olaparib through regulating FOXM1 and Exo1 expression

open access: yesScientific Reports, 2021
Poly (ADP-ribose) polymerase (PARP) inhibitors offer a significant clinical benefit for triple-negative breast cancers (TNBCs) with BRCA1/2 mutation. However, the narrow clinical indication limits the development of PARP inhibitors.
Yu Li   +5 more
doaj   +1 more source

Recognition and Positioning of Fresh Tea Buds Using YOLOv4-lighted + ICBAM Model and RGB-D Sensing

open access: yesAgriculture, 2023
To overcome the low recognition accuracy, slow speed, and difficulty in locating the picking points of tea buds, this paper is concerned with the development of a deep learning method, based on the You Only Look Once Version 4 (YOLOv4) object detection ...
Shudan Guo   +7 more
doaj   +1 more source

A Powerful Optimization Tool for Analog Integrated Circuits Design [PDF]

open access: yes, 2013
This paper presents a new optimization tool for analog circuit design. Proposed tool is based on the robust version of the differential evolution optimization method. Corners of technology, temperature, voltage and current supplies are taken into account
Jakovenko, J., Kubar, M.
core   +1 more source

Ergonomic Chair Design by Fusing Qualitative and Quantitative Criteria using Interactive Genetic Algorithms [PDF]

open access: yes, 2008
This paper emphasizes the necessity of formally bringing qualitative and quantitative criteria of ergonomic design together, and provides a novel complementary design framework with this aim. Within this framework, different design criteria are viewed
Brintrup, Alexandra Melike   +2 more
core   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein   +3 more
wiley   +1 more source

Multifaceted design optimization for superomniphobic surfaces [PDF]

open access: yesScience Advances, 2019
Versatile computational tools are developed to solve the design optimization challenge for structured nonwetting surfaces. Superomniphobic textures are at the frontier of surface design for vast arrays of applications. Despite recent substantial advances
J. Panter, Yonas Gizaw, H. Kusumaatmaja
semanticscholar   +1 more source

Benchmarking five global optimization approaches for nano-optical shape optimization and parameter reconstruction

open access: yes, 2019
Numerical optimization is an important tool in the field of computational physics in general and in nano-optics in specific. It has attracted attention with the increase in complexity of structures that can be realized with nowadays nano-fabrication ...
Burger, Sven   +5 more
core   +1 more source

Stereotactic Body Radiation Therapy for Pediatric, Adolescent, and Young Adult Patients With Osteosarcoma: Local Control Outcomes With Dosimetric Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Osteosarcoma is a radioresistant tumor that may benefit from stereotactic body radiation therapy (SBRT) for locoregional control in metastatic/recurrent disease. We report institutional practice patterns, outcomes, toxicity, and failures in osteosarcoma patients treated with SBRT.
Jenna Kocsis   +13 more
wiley   +1 more source

Robust Design Optimization and Emerging Technologies for Electrical Machines: Challenges and Open Problems

open access: yesApplied Sciences, 2020
The bio-inspired algorithms are novel, modern, and efficient tools for the design of electrical machines. However, from the mathematical point of view, these problems belong to the most general branch of non-linear optimization problems, where these ...
T. Orosz   +6 more
semanticscholar   +1 more source

Performance-based optimization of structures: theory and applications [PDF]

open access: yes, 2005
Performance-based Optimization of Structures introduces a method to bridge the gap between optimization theory and its practical applications to structural engineering.
Liang, Qing Quan
core  

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