Results 71 to 80 of about 5,060,080 (299)

A design space for event-centric displays in public libraries

Frontiers in Computer Science
We present a design space for displays in public libraries; more specifically public displays related to events taking place in the library. The design space is developed from the perspective of the librarians and is intended to support libraries in ...
Alix Ducros, Aurélien Tabard, Aurélien Tabard, Peter Dalsgaard, Raphaelle Bats, Eva Eriksson   +5 more
doaj   +1 more source

Design of the Spitzer Space Telescope Heritage Archive [PDF]

, 2009
It is predicted that Spitzer Space Telescope’s cryogen will run out in April 2009, and the final reprocessing for the cryogenic mission is scheduled to end in April 2011, at which time the Spitzer archive will be transferred to the NASA/IPAC Infrared ...
Alexov, A., Berriman, G. B., Capak, P., Good, J., Groom, S., Handley, T., Kirkpatrick, J. D., Lacy, M., Laher, Russ R., Laine, S., Legassie, M., Levine, Deborah, Ly, L., Roby, T., Wu, X.   +14 more
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Thermal design of the space shuttle external tank [PDF]

, 1985
The shuttle external tank thermal design presents many challenges in meeting the stringent requirements established by the structures, main propulsion systems, and Orbiter elements.
Bachrtel, F. D., Gray, C., Stuckey, J. M., Vaniman, J. L., Widofsky, B.   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Support Vector Regression Approach to Predict the Design Space for the Extraction Process of Pueraria lobata

Molecules, 2018
A support vector regression (SVR) method was introduced to improve the robustness and predictability of the design space in the implementation of quality by design (QbD), taking the extraction process of Pueraria lobata as a case study.
Yaqi Wang, Yuanzhen Yang, Jiaojiao Jiao, Zhenfeng Wu, Ming Yang   +4 more
doaj   +1 more source

Guaranteed passive parameterized macromodeling by using Sylvester state-space realizations [PDF]

, 2013
A novel state-space realization for parameterized macromodeling is proposed in this paper. A judicious choice of the state-space realization is required in order to account for the assumed smoothness of the state-space matrices with respect to the design
Dhaene, Tom, Ferranti, Francesco, Knockaert, Luc, Samuel, Elizabeth Rita   +3 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source