Results 81 to 90 of about 2,150,399 (264)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Styling the Future. A philosophical account of scenarios & design [PDF]
, 2015 Since the end of the 1980s – the Decade of Style (Mort, 1996) – the value of style in design has fallen. Recent times (Whicher et al., 2015) see a focus on style as a sign of design’s immaturity, while a more mature design should be attending to process,
Brassett, Jamie, O'Reilly, John
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
O uso do design thinking como ferramenta no processo de inovação em bibliotecas
Encontros Bibli, 2017 http://dx.doi.org/10.5007/1518-2924.2017v22n49p59 Este artigo tem como finalidade apresentar estudos de casos de sucesso do uso da abordagem do Design Thinking (DT) em bibliotecas e teve como objetivo estudar o Design Thinking através da história, as ...
Diana Marcela Bernal Ramírez +1 more
doaj +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Politics Design: A Solution-Oriented Approach to Political Science
PoliticonPost-behavioralist critiques are a crucial foundation for changes in previous apolitical political research. Politics should be an academic instrument and a response to humanity’s challenges. Political design seeks to criticize the dominance of the logic
Wawan Sobari
doaj +1 more source
Uncertainty, learning design, and interdisciplinarity: systems and design thinking in the school classroom [PDF]
, 2014 This paper explores aspects of learning design for design thinking within a small (circa 100) remote rural secondary (12-18 year old) school in the Highlands of Scotland.
Macintyre, Ronald
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The effect of critical thinking on making the right decisions in the new venture process [PDF]
, 2019 The design of a new venture is similar to the engineering design process. With systematic approaches, it is possible to increase foresight and reduce the complexity of the engineering design process.
Bailey, Mark, Yaldız, Naz
core +2 more sources
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source