Results 21 to 30 of about 18,110 (202)

Promising Antifungal Activity of Encephalartos laurentianus de Wild against Candida albicans Clinical Isolates: In Vitro and In Vivo Effects on Renal Cortex of Adult Albino Rats

Journal of Fungi, 2022
Candida albicans can cause various infections, especially in immunocompromised patients. Its ability to develop resistance to the current antifungal drugs as well as its multiple virulence factors have rendered the problem even more complicated. Thus, in
Walaa A. Negm, Mona El-Aasr, Ghada Attia, Moneerah J. Alqahtani, Rania Ibrahim Yassien, Amal Abo Kamer, Engy Elekhnawy   +6 more
doaj   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

The novel desmin variant p.Leu115Ile is associated with a unique form of biventricular Arrhythmogenic Cardiomyopathy.

Canadian Journal of Cardiology, 2020
BACKGROUND Arrhythmogenic Cardiomyopathy (AC) is a heritable myocardial disorder and a major cause of sudden cardiac death. It is typically caused by mutations in desmosomal genes.
Alexandros Protonotarios, A. Brodehl, A. Asimaki, J. Jager, Ellie Quinn, C. Stanasiuk, S. Ratnavadivel, M. Futema, M. Akhtar, T. Gossios, M. Ashworth, K. Savvatis, V. Walhorn, D. Anselmetti, P. Elliott, P. Syrris, H. Milting, L. Lopes   +17 more
semanticscholar   +1 more source

Spatial Fuzzy C-means dan Rapid Region Merging untuk Pemisahan Sel Kanker Payudara

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2017
Segmentation and overlapped cells separation are important phases in microscopic image processing of breast cancer, because the accuracy of overlapped cells separation result determines the accuracy of breast cancer cell calculation. The amount of breast
Desmin Tuwohingide, Chastine Fatichah
doaj   +1 more source

Desmin Modulates Muscle Cell Adhesion and Migration

Frontiers in Cell and Developmental Biology, 2022
Cellular adhesion and migration are key functions that are disrupted in numerous diseases. We report that desmin, a type-III muscle-specific intermediate filament, is a novel cell adhesion regulator.
Coralie Hakibilen, Florence Delort, Marie-Thérèse Daher, Pierre Joanne, Eva Cabet, Olivier Cardoso, Fany Bourgois-Rocha, Cuixia Tian, Eloy Rivas, Marcos Madruga, Ana Ferreiro, Ana Ferreiro, Alain Lilienbaum, Patrick Vicart, Onnik Agbulut, Sylvie Hénon, Sabrina Batonnet-Pichon   +16 more
doaj   +1 more source

Desmin prevents muscle wasting, exaggerated weakness and fragility, and fatigue in dystrophic mdx mouse

Journal of Physiology, 2020
Desmin, similar to dystrophin, is associated with costameric structures bridging sarcomeres to the extracellular matrix. Deletion of the desmin gene in mdx mice [double knockout (DKO) mice] induces marked muscle weakness and fatigue resistance compared ...
A. Ferry, J. Messéant, A. Parlakian, M. Lemaître, Pauline Roy, C. Delacroix, A. Lilienbaum, Yeranuhi Hovhannisyan, D. Furling, A. Klein, Zhenlin Li, O. Agbulut   +11 more
semanticscholar   +1 more source

AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies

Gene Therapy, 2020
Mutations in the human desmin gene cause autosomal-dominant and recessive cardiomyopathies and myopathies with marked phenotypic variability. Here, we investigated the effects of adeno-associated virus (AAV)-mediated cardiac wild-type desmin expression ...
T. Ruppert, M. Heckmann, K. Rapti, D. Schultheis, A. Jungmann, H. Katus, L. Winter, N. Frey, C. Clemen, R. Schröder, O. Müller   +10 more
semanticscholar   +1 more source

Embryonal Rhabdomyosarcoma in Middle Ear: A Rare Case Report [PDF]

Journal of Clinical and Diagnostic Research, 2021
Rhabdomyosarcoma (RMS) in middle ear and mastoid are uncommon. Presentation of RMS in these sites include purulent or blood stained discharge, polypoidal mass and granulation tissue.
Anita Omhare, Sanjeev Kumar Singh, Geeta Maurya, Roopak Aggarwal, Sanjay Kannaujia   +4 more
doaj   +1 more source

Restrictive Cardiomyopathy is Caused by a Novel Homozygous Desmin (DES) Mutation p.Y122H Leading to a Severe Filament Assembly Defect

Genes, 2019
Here, we present a small Iranian family, where the index patient received a diagnosis of restrictive cardiomyopathy (RCM) in combination with atrioventricular (AV) block.
A. Brodehl, Seyed Ahmad Pour Hakimi, C. Stanasiuk, S. Ratnavadivel, D. Hendig, A. Gaertner, B. Gerull, J. Gummert, L. Paluszkiewicz, H. Milting   +9 more
semanticscholar   +1 more source

Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2019
Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autophagy ...
Xiucui Ma, K. Mani, Haiyan Liu, A. Kovács, J. Murphy, Layla Foroughi, B. A. French, C. Weinheimer, A. Kraja, I. Benjamin, Joseph A. Hill, A. Javaheri, A. Diwan   +12 more
semanticscholar   +1 more source