Results 101 to 110 of about 18,623 (291)

Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro

International Journal of Cosmetic Science, EarlyView.
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree, Bradley B. Jarrold, Olivia Kent, Matthew C. Ehrman, Timothy J. Hawkins, Viktor Korolchuk, Camila Pereira Braga, John M. Snowball, Makio Tamura, Tomohiro Hakozaki, Akira Matsubara, John E. Oblong, Max Brown   +12 more
wiley   +1 more source

Lots of autoantibodies equal lupus? [PDF]

, 2013
Autoantibodies may be found years before an autoimmune disease becomes clinically apparent. For systemic lupus erythematosus (SLE), those to RNA-binding proteins, to phospholipids, and to double-stranded DNA, in particular, have been found in sera of SLE
Aringer, M, Vital, E
core   +1 more source

Arrhythmogenic Cardiomyopathy: Towards Genotype Based Diagnoses and Management

Journal of Cardiovascular Electrophysiology, EarlyView.
To improve arrhythmogenic cardiomyopathy (ACM) patient care four pillars of ACM research are necessary. The first pillar to improve ACM is cohort studies in which the genotype‐specific natural history of disease is described, and subsequently genotype‐specific risk calculators can be developed, such as the DSP and PLN risk calculators.
Steven A. Muller, Giorgia Bertoli, Jianan Wang, Alessio Gasperetti, Moniek G. P. J. Cox, Hugh Calkins, Anneline S. J. M. te Riele, Daniel P. Judge, Mario Delmar, Richard N. W. Hauer, Gerard J. J. Boink, Marina Cerrone, J. Peter van Tintelen, Cynthia A. James   +13 more
wiley   +1 more source

miRNA- and cytokine-associated extracellular vesicles mediate squamous cell carcinomas

Journal of Extracellular Vesicles, 2020
Exosomes, or small extracellular vesicles (sEVs), serve as intercellular messengers with key roles in normal and pathological processes. Our previous work had demonstrated that Dsg2 expression in squamous cell carcinoma (SCC) cells enhanced both sEV ...
Joseph P. Flemming, Brianna L. Hill, Mohammed W. Haque, Jessica Raad, Claudine S. Bonder, Larry A. Harshyne, Ulrich Rodeck, Adam Luginbuhl, James K. Wahl, Kenneth Y. Tsai, Peter J. Wermuth, Andrew M. Overmiller, Mỹ G. Mahoney   +12 more
doaj   +1 more source

Paraneoplastic pemphigus: insight into the autoimmune pathogenesis, clinical features and therapy [PDF]

, 2017
Paraneoplastic pemphigus is a rare autoimmune skin disease that is always associated with a neoplasm. Usually, oral, skin, and mucosal lesions are the earliest manifestations shown by paraneoplastic pemphigus patients.
Andrea Ciofalo, Biagio Didona, Bialy-Golan, Dario Didona, Elisa Moliterni, Giannicola Iannella, Giovanni Paolino, Giuseppe Magliulo, Guido Granata, Hainsworth, Martínez De Pablo, Matz, Michele Donati, Mutasim, Nguyen, Patricia Ranuzzi, Santo Mercuri, Schepens, Stefano Calvieri, Su, Vincenzo Falasca, Zimmermann   +21 more
core   +2 more sources

Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces

International Journal of Molecular Sciences, 2019
Desmoglein 3 (Dsg3) plays a crucial role in cell-cell adhesion and tissue integrity. Increasing evidence suggests that Dsg3 acts as a regulator of cellular mechanotransduction, but little is known about its direct role in mechanical force transmission ...
Jutamas Uttagomol, U. Ahmad, A. Rehman, Yunying Huang, A. Laly, Angray S. Kang, J. Soetaert, R. Chance, M. Teh, J. Connelly, H. Wan   +10 more
semanticscholar   +1 more source

An imbalance in Akt/mTOR is involved in the apoptotic and acantholytic processes in a mouse model of pemphigus vulgaris [PDF]

, 2009
Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by the presence of IgG autoantibodies against Dsg3. Our aim was to investigate the molecular events implicated in the development and localization of apoptosis and acantholysis in ...
España, A. (Agustín), Lopez-Picazo, J.M. (José M.), Lopez-Zabalza, M.J. (María Jesús), Marquina, M. (Miren), Pelacho, B. (Beatriz), Pretel, M. (Maider)   +5 more
core   +1 more source

Clinical Features and Current Therapeutic Approaches to Monilethrix: A Systematic Review

Pediatric Dermatology, EarlyView.
ABSTRACT Monilethrix is a rare congenital hair disorder characterized by fragile, beaded hair shafts due to mutations in various keratin or desmoglein 4 genes. A systematic review of 24 studies (16 pediatric only, 3 mixed adult and pediatric, 3 adult only, and 2 unspecified) evaluating various treatment modalities identified topical and oral minoxidil ...
Adam C. Yu, Dana Koroluk, Fatmah Alzahrani   +2 more
wiley   +1 more source

Evaluation of autoantibodies to desmoglein-2 in dogs with and without cardiac disease

Scientific Reports, 2023
Autoantibodies to desmoglein-2 have been associated with arrhythmogenic right ventricular cardiomyopathy (ARVC) in people. ARVC is a common disease in the Boxer dog.
Ashley L. Walker, Ronald H. L. Li, Nghi Nguyen, Carina E. Jauregui, Kathryn M. Meurs, Allison L. Gagnon, Joshua A. Stern   +6 more
doaj   +1 more source

A global perspective of arrhythmogenic right ventricular cardiomyopathy. [PDF]

, 2012
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a progressive inherited heart disease characterized by ventricular arrhythmias and sudden cardiac death especially in the young. ARVC has been traditionally associated with the Mediterranean basin,
Alhashemi, M, Elmaghawry, M, Yacoub, MH, Zorzi, A   +3 more
core   +1 more source