Results 121 to 130 of about 18,623 (291)

Glutenbedingte Hauterkrankungen: Klinik, Diagnostik und Therapie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 7, Page 857-868, July 2025.
Zusammenfassung Glutenbedingte Erkrankungen stellen ein Spektrum verschiedener klinischer Erscheinungsformen dar, die durch die Aufnahme von Gluten bei genetisch anfälligen Personen ausgelöst werden. Zu den glutenbedingten Erkrankungen gehören die Zöliakie und die Nicht‐Zöliakie‐Glutensensitivität (NCGS). Glutenbedingte Erkrankungen zeichnen sich durch
Dario Didona, Roberto Maglie, Farzan Solimani   +2 more
wiley   +1 more source

Plakophilins, Desmogleins, and Pemphigus: The Tail Wagging the Dog [PDF]

Journal of Investigative Dermatology, 2014
The importance of desmosomal cell adhesion to human health is evidenced by the autoimmune disease pemphigus vulgaris (PV), in which autoantibodies against the extracellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering of the skin and mucous membranes. Tucker et al.
Christoph T. Ellebrecht, Aimee S. Payne
openaire   +3 more sources

Pathological IgE Production in Inborn Errors of Immunity and Beyond

Immunological Reviews, Volume 332, Issue 1, July 2025.
ABSTRACT In this review, we examine different mechanisms for the generation of pathological IgE through the study of inborn errors of immunity (IEI). In particular, we focus on IEIs that are susceptible to atopic disease, such as severe eczema, eosinophilia, and/or food anaphylaxis; this group of approximately 50 genes has been coined primary atopic ...
Cindy S. Ma, Peter S. Hsu
wiley   +1 more source

The progestin receptor interactome in the female mouse hypothalamus: Interactions with synaptic proteins are isoform specific and ligand dependent [PDF]

, 2017
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study,
Acharya, Kalpana D, Denner, Larry, Edwards, Dean P, Harling, Moriah, Huang, Shixia, Im, Dana D, Lichti, Cheryl F, Nettles, Sabin A, Pattanayak, Cassandra, Sellers, Katherine J, Srivastava, Deepak P, Tetel, Marc J, Vardar-Ulu, Didem   +12 more
core   +3 more sources

Functional Effects of the TMEM43 Ser358Leu Mutation in the Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy [PDF]

, 2012
Background: The Ser358Leu mutation in TMEM43, encoding an inner nuclear membrane protein, has been implicated in arrhythmogenic right ventricular cardiomyopathy (ARVC). The pathogenetic mechanisms of this mutation are poorly understood.
Ahmad, Ferhaan, McDonough, Barbara Anne, Rajkumar, Revathi, Seidman, Christine Edry, Sembrat, John C   +4 more
core   +5 more sources

Topographical variations in the skin barrier and their role in disease pathogenesis

Journal of the European Academy of Dermatology and Venereology, Volume 39, Issue 7, Page 1228-1238, July 2025.
Unlike the gut, the skin appears uniform at first glance. However, histological and molecular biological research has revealed significant regional variations in the composition and function of its main barrier elements. In this review, we describe the topographical differences of four barrier elements in healthy skin: microbiome, chemical, physical ...
Z. Dajnoki, A. Kapitány, K. Eyerich, S. Eyerich, D. Törőcsik, A. Szegedi   +5 more
wiley   +1 more source

Case Report: Delayed recurrence of staphylococcal scalded skin syndrome in an extremely low birth weight infant

Frontiers in Pediatrics
Preterm infants have well-documented deficiencies in their innate and adaptive immune responses, which are indirectly correlated with their gestational age at birth.
Sara M. Hooper, Camille M. Fung, Camille M. Fung, Carrie Torr, Carrie Torr, Shelley M. Lawrence, Shelley M. Lawrence   +6 more
doaj   +1 more source

c-Src/Cav1-dependent activation of the EGFR by Dsg2. [PDF]

, 2016
The desmosomal cadherin, desmoglein 2 (Dsg2), is deregulated in a variety of human cancers including those of the skin. When ectopically expressed in the epidermis of transgenic mice, Dsg2 activates multiple mitogenic signaling pathways and increases ...
Brennan-Crispi, Donna M., Cooper, Felicia, Deguchi, Takahiro, Mahoney, Mỹ G., McGuinn, Kathleen P., Overmiller, Andrew M., Peltonen, Sirkku, Roberts, Brett J., Wahl, James K.   +8 more
core   +2 more sources

Mapping of Adenovirus of serotype 3 fibre interaction to desmoglein 2 revealed a novel ‘non-classical’ mechanism of viral receptor engagement

Scientific Reports, 2018
High-affinity binding of the trimeric fibre protein to a cell surface primary receptor is a common feature shared by all adenovirus serotypes. Recently, a long elusive species B adenovirus receptor has been identified.
E. Vassal-Stermann, Manon Mottet, C. Ducournau, F. Iseni, Charles Vragniau, Hongjie Wang, C. Zubieta, A. Lieber, P. Fender   +8 more
semanticscholar   +1 more source

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, Volume 12, Issue 23, June 20, 2025.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source