Results 131 to 140 of about 18,623 (291)

Suppression of the Immune Response Against Exogenous Desmoglein 3 in Desmoglein 3 Knockout Mice: An Implication for Gene Therapy [PDF]

Journal of Investigative Dermatology, 2003
Gene therapies for recessive genetic diseases may provoke unwanted immune responses against the introduced gene product because patients, especially those with null mutation of a certain protein, have no tolerance for the protein of interest. This study used desmoglein 3 knockout (Dsg3-/-) mice as a disease model for a genetic defect in DSG3, to ...
Masayuki Amagai, Miyo Aoki, Shigeo Koyasu, Takayuki Ota, Takeji Nishikawa, Reiko Harada, Manabu Ohyama, Kazuyuki Tsunoda   +7 more
openaire   +3 more sources

Squamous cell carcinoma of the soft palate associated with autoantibodies to desmoglein 1 and 3

Dermatology Practical & Conceptual, 2013
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Yoshifumi Maumi, Reiko Suzaki, Naoko Ito, Mizuki Sawada, Sumiko Ishizaki, Mariko Fujibayashi, Motohiko Aiba, Hiroyuki Kaneko, Masaru Tanaka   +8 more
doaj   +1 more source

Sita‐ and saxagliptin use and autoantibodies to autoimmune bullous diseases: A cross‐sectional study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Sören Dräger, Claudia Kauderer, Svenja Meyhöfer, Leonie Dräger, Jens U. Marquardt, Ralf J. Ludwig, Stephan Arndt, Katharina Boch, Katja Bieber   +8 more
wiley   +1 more source

Prolonged Vancomycin‐Induced Linear IgA Disease in a Patient With Renal Failure

JEADV Clinical Practice, Volume 4, Issue 2, Page 535-539, June 2025.
ABSTRACT A 64‐year‐old man with pneumococcal septic shock and subsequent renal failure underwent treatments with antibiotics including intravenous vancomycin (VCM). Blistering skin lesions appeared 10 days after the initiation of VCM. When the patient was transferred to us 5 months later, blisters with erythema were still observed on the abdomen and ...
Kaori Takezawa, Reiko Noborio, Yuki Nomura, Takahiro Kiyohara, Mako Mine, Takashi Hashimoto   +5 more
wiley   +1 more source

A Comparative Analysis of the Peptide Repertoires of HLA–DR Molecules Differentially Associated With Rheumatoid Arthritis [PDF]

, 2017
[Objective] To evaluate similarity of the peptide repertoires bound to HLA–DR molecules that are differentially associated with rheumatoid arthritis (RA), and to define structural features of the shared peptides. [Methods] Peptide pools bound to HLA–
Alvarez, Alvarez, Alvarez, Andreatta, Bowes, Chicz, Chicz, Collado, Cutbush, Dessen, Espinosa, Eyre, Garcia-Medel, Gregersen, Helm-van Mil, Hennecke, Hill, Huizinga, Imboden, James, Jaraquemada, Juan, Klareskog, Klareskog, Marti, Massardo, Muixi, Muixi, Muntasell, O'Sullivan, Ollier, Ramos, Raychaudhuri, Rebai, Rosloniec, Rosloniec, Sanchez, Scally, Seldin, Seward, Yelamos   +40 more
core   +1 more source

The molecular genetic analysis of the expanding pachyonychia congenita case collection [PDF]

, 2014
BACKGROUND: Pachyonychia congenita (PC) is a rare autosomal dominant keratinizing disorder characterized by severe, painful, palmoplantar keratoderma and nail dystrophy, often accompanied by oral leucokeratosis, cysts and follicular keratosis.
Al-Asadi, E., Hansen, C. D., McLean, W. H. I., Milstone, L. M., O'Toole, E., Schwartz, M. E., Shepherd, A. A., Smith, F. J. D., Sprecher, E., Wilson, N. J.   +9 more
core   +2 more sources

Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase

Scientific Reports, 2017
Intestinal epithelial barrier properties are maintained by a junctional complex consisting of tight junctions (TJ), adherens junctions (AJ) and desmosomes.
Hanna Ungewiss, Franziska Vielmuth, Shintaro T. Suzuki, Andreas Maiser, H. Harz, H. Leonhardt, D. Kugelmann, N. Schlegel, J. Waschke   +8 more
semanticscholar   +1 more source

IFITM1/OVOL1 Axis Is a Novel Regulator of the Expansion of the Limbal Epithelial Stem/Early Transient Amplifying Cell Population

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
The study demonstrates that Interferon Induced Transmembrane Protein 1(IFITM1) is positively correlated with the expansion of corneal stem/epithelial transient amplifying (eTA) cells following corneal injury. This expansion is partly attributed to the inhibition of Ovo like zinc finger 1 (OVOL1), a negative regulator of epithelial cell proliferation ...
Huimin Jiang, Parisa Foroozandeh, Nihal Kaplan, Dan Xu, Wending Yang, Xiaolin Qi, Elif Kayaalp Nalbant, Elwin D. Clutter, Yongling Zhu, Jian Xu, Matthew John Schipma, Ziyou Ren, Han Peng   +12 more
wiley   +1 more source

Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome

Clinical and Translational Medicine, Volume 15, Issue 5, May 2025.
EVs were isolated from plasma of ME/CFS patients and healthy controls at baseline, and 15 min and 24 h postexercise. Untargeted proteomics revealed dysregulation in energy metabolism, the complement system, and the endoplasmic reticulum stress response. Changes in EV protein levels postexercise are associated with post‐exertional malaise.
Katherine A. Glass, Ludovic Giloteaux, Sheng Zhang, Maureen R. Hanson   +3 more
wiley   +1 more source

Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells. [PDF]

, 2013
IntroductionThe purpose of this study is to identify target proteins that may play important functional roles in oral cancer stem-like cells (CSCs) using mass spectrometry-based quantitative proteomics.MethodsSphere-formation assays were performed on ...
Feng, Sizhe, Hu, Shen, Liu, Xiaojun, Misuno, Kaori   +3 more
core   +1 more source