Results 271 to 280 of about 18,623 (291)
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British Journal of Dermatology, 1999
Acantholytic blisters in pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by a dissociation of desmosomes mediated by autoantibodies against desmoglein (Dsg) 3 and Dsg 1, respectively. The blistering occurs at the suprabasilar level in PV and at the subcorneal level in PF, which corresponds to the distribution of target antigens in the ...
Hitoshi Akiba +6 more
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Acantholytic blisters in pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are caused by a dissociation of desmosomes mediated by autoantibodies against desmoglein (Dsg) 3 and Dsg 1, respectively. The blistering occurs at the suprabasilar level in PV and at the subcorneal level in PF, which corresponds to the distribution of target antigens in the ...
Hitoshi Akiba +6 more
openaire +3 more sources
Atypical pemphigus: autoimmunity against desmocollins and other non-desmoglein autoantigens.
Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2020In this review, we recap current knowledge about non-desmoglein autoantigens in atypical forms of autoimmune pemphigus. More than 50 keratinocyte proteins, including adhesion molecules, receptors and enzymes as well as mitochondrial proteins can be ...
B. Gualtieri, A. Marzano, S. Grando
semanticscholar +1 more source
Molecular organization of the desmoglein-plakoglobin complex [PDF]
Journal of Cell Science, 1998 ABSTRACT Different epithelial intercellular junctions contain distinct complexes incorporating plakoglobin. In adherens junctions, plakoglobin interacts with two molecules, the transmembrane adhesion protein of the cadherin family (e.g. E-cadherin) and α-catenin.
Alexander Z. Averbakh +3 more
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Experimental Cell Research, 1994
Desmosomes are junctions between epithelial, myocardiac, and certain other kinds of cells. They represent plasma membrane domains enriched in specific transmembrane glycoproteins, notably desmoglein (Dsg) and desmocollin (Dsc), both of which have recently been identified as members of the larger family of Ca(2+)-dependent cell adhesion molecules, the ...
Werner W. Franke +2 more
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Desmosomes are junctions between epithelial, myocardiac, and certain other kinds of cells. They represent plasma membrane domains enriched in specific transmembrane glycoproteins, notably desmoglein (Dsg) and desmocollin (Dsc), both of which have recently been identified as members of the larger family of Ca(2+)-dependent cell adhesion molecules, the ...
Werner W. Franke +2 more
openaire +3 more sources
Desmoglein-2 overexpression predicts poor prognosis in hepatocellular carcinoma patients.
European Review for Medical and Pharmacological Sciences, 2018OBJECTIVE Desmoglein-2 (Dsg2) plays a crucial role in the assembly and adhesion of desmosomes. The absent or aberrant expression of Dsg2 was reported to be associated with the progression of varies human cancers.
C. Han +6 more
semanticscholar +1 more source
Desmoglein as a target in autoimmunity and infection
Journal of the American Academy of Dermatology, 2003Clinical phenotypes of most diseases are complex. However, once the mechanism behind the scene is clarified, the nature shows amazing beauty. There is a simple logic behind a complex disease. The exact molecular mechanism of the blister formation in staphylococcal scalded skin syndrome (SSSS) remained to be elucidated for 3 decades since exfoliative ...
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Pemphigus vulgaris Antigen Is a Desmosomal Desmoglein
Dermatology, 1994Because pemphigus vulgaris antigen (PVA) is homologous to desmogleins which are in desmosomes, we asked whether PVA is also localized to desmosomes. Immunogold electron microscopy was used to localize binding of PV antibodies. Rabbit antibodies raised against fusion proteins containing the extracellular portion of PVA bound to desmosomes of cultured ...
John R. Stanley +3 more
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Australasian Journal of Dermatology, 2014
A 79 year-old male patient presented clinically as a typical case of pemphigus foliaceus. He displayed a seborrhoeic pattern of crusting and erosions with an absence of oral involvement. Surprisingly, a biopsy showed suprabasilar acantholysis and direct immunofluorescence consistent with pemphigus vulgaris.
Benjamin Carew, Godfrey Wagner
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A 79 year-old male patient presented clinically as a typical case of pemphigus foliaceus. He displayed a seborrhoeic pattern of crusting and erosions with an absence of oral involvement. Surprisingly, a biopsy showed suprabasilar acantholysis and direct immunofluorescence consistent with pemphigus vulgaris.
Benjamin Carew, Godfrey Wagner
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Desmoglein 1 and desmoglein 3 as autoimmune target of herpetiform pemphigus
Journal of Dermatological Science, 1998Takeji Nishikawa +6 more
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