Results 131 to 140 of about 13,090 (254)

Chimeric Antigen Receptor T‐Cell Therapy: More Than an Anti‐Cancer Drug

HLA, Volume 107, Issue 1, January 2026.
ABSTRACT Initially, chimeric antigen receptor (CAR) T‐cell therapy was developed to eliminate malignant B cells in haematological B‐cell malignancies by targeting CD19 and B‐cell maturation antigen. This approach achieved notable success, resulting in (malignant) B‐cell depletion and inducing clinical remission in cancer patients.
Hannah C. M. Schenk, Ilse Gille, Carolt Arana, Jordi Rovira, Eduard Palou, Fritz Diekmann, Dave L. Roelen, Mirjam H. M. Heemskerk, Sebastiaan Heidt   +8 more
wiley   +1 more source

Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination

Nature Communications, 2018
The epidermis is a multi-layered epithelium formed by the differentiation of basal cells and movement into suprabasal layers. Here the authors define a role for the desmosomal cadherin desmoglein-1 in promoting the delamination of basal cells by ...
Oxana Nekrasova, Robert M. Harmon, Joshua A. Broussard, Jennifer L. Koetsier, Lisa M. Godsel, Gillian N. Fitz, Margaret L. Gardel, Kathleen J. Green   +7 more
doaj   +1 more source

The Desmosomal Protein Desmoglein 1 Aids Recovery of Epidermal Differentiation after Acute UV Light Exposure [PDF]

, 2014
Jodi Johnson, Jennifer L. Koetsier, Anna Sirico, Ada T. Agidi, Dario Antonini, Caterina Missero, Kathleen J. Green   +6 more
openalex   +1 more source

JAK Inhibitors as a Novel Approach to Autoimmune Bullous Diseases: A Review

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Autoimmune bullous diseases (AIBDs) are a group of chronic disorders characterized by blister formation resulting from abnormal immune responses. Janus kinase (JAK) inhibitors have emerged as promising therapeutic agents for AIBDs. This review discusses the use of JAK inhibitors—such as upadacitinib, baricitinib, tofacitinib, and abrocitinib, among ...
Olga Olisova, Yuliya Kolesova, Natalia Teplyuk, Ekaterina Grekova, Leyi Ni, Alina Mardanova, Karim Karray, Anastasiia Tikhonova, Anfisa Lepekhova, Jaime Piquero-Casals   +9 more
wiley   +1 more source

Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration. [PDF]

J Cell Biol, 2023
Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ.   +9 more
europepmc   +1 more source

The Transition from Pemphigus Foliaceus to Pemphigus Vegetans—An Intriguing Phenomenon within the Spectrum of Autoimmune Blistering Diseases: A Case Report

Dermato
Pemphigus vegetans and pemphigus foliaceus are rare autoimmune blistering diseases characterized by the disruption of desmosomal adhesion proteins, particularly desmoglein 3 and desmoglein 1.
Olguța Anca Orzan, Liliana Gabriela Popa, Iulia Badiu, Ana Ion, Călin Giurcăneanu, Beatrice Bălăceanu-Gurău, Irina Tudose   +6 more
doaj   +1 more source

Figure S6 from Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner

, 2023
Alejandra Valenzuela-Iglesias, Hope E. Burks, Christopher R. Arnette, Amulya Yalamanchili, Oxana Nekrasova, Lisa M. Godsel, Kathleen J. Green   +6 more
openalex   +1 more source

Rilzabrutinib-induced transition from pemphigus vulgaris to pemphigus foliaceous: case report and review of the literature

Dermatology Reports
The discovery of the role of Bruton’s Tyrosine Kinase (BTK) in inflammation and autoimmunity has recently led to the development of BTK inhibitors for the treatment of autoimmune diseases, including pemphigus vulgaris.
Christian Ciolfi, Jacopo Tartaglia, Francesca Pampaloni, Laura Fagotto, Andrea Sechi, Mauro Alaibac   +5 more
doaj  

Dermpath and Clinic: Pemphigus herpetiformis with vacuolar interface dermatitis and autoantibodies against desmoglein 1 and 3

, 2021
Bram D. van Rhijn, Jorien van der Schaft, Barbara Horváth, Marijke R. van Dijk, Hendri H. Pas   +4 more
openalex   +2 more sources

Desmoglein 1 Deficiency Causes Lethal Skin Blistering [PDF]

Journal of Investigative Dermatology, 2019
Daniela Kugelmann, Mariya Y. Radeva, Volker Spindler, Jens Waschke   +3 more
openaire   +2 more sources