Results 211 to 220 of about 13,090 (254)

Rituximab resistant pemphigus vulgaris successfully treated with obinutuzumab. [PDF]

JAAD Case Rep
Hiel MAJ, Diercks GFH, Bolling MC, Bremer J, Meijer JM, Horváth B.   +5 more
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Desmoglein 3 acts as a potential oncogene in promoting cancer cell migration and invasion through regulating AP-1 and PKC dependent-Ezrin activation

, 2016
Huan Wan, Louise Brown, EA O'Toole
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Immunolocalisation of desmoglein‐1 in equine muzzle skin

Equine Veterinary Journal, 2006
Desmogleins (Dsgs) are glycoproteins of the cadherin family that allow the formation of desmosomes via a Ca2+-dependent homophilic interaction. Desmosomes are cell-cell adhesion systems that contribute to the mechanical integrity of epidermis by linking to keratin intermediate filaments and, therefore, connecting the cytoskeleton of adjacent ...
MIRAGLIOTTA, VINCENZO, Donadio E, FELICIOLI, ANTONIO, PODESTA', ADRIANO, RICCIARDI, MARIA PAOLA, Ceccardi S, ABRAMO, FRANCESCA   +6 more
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Changes in desmoglein 1 expression and subcellular localization in cultured keratinocytes subjected to anti‐desmoglein 1 pemphigus autoimmunity

Journal of Cellular Physiology, 2006
AbstractThe complexity of pemphigus acantholysis together with the weak expression of desmoglein 1 (Dsg1) in cultured keratinocytes have made the study on the pathogenic action of anti‐Dsg1 antibodies quite difficult. The pathophysiology of the acantholytic phenomenon could depend on the reduction of Dsg1 adhesion function occurring after its massive ...
CIRILLO N, GOMBOS F, LANZA, Alessandro
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Herpetiform pemphigus without anti‐desmoglein 1/3 autoantibodies

The Journal of Dermatology, 2010
AbstractWe report a patient with herpetiform pemphigus who was negative for autoantibodies to desmoglein (Dsg)1 or 3. He had erythemas with vesicles lining the margins on the trunk and extremities. Histopathology revealed intraepidermal blister with prominent eosinophil infiltration.
Hiroko, Nakashima, Manabu, Fujimoto, Rei, Watanabe, Nobuko, Ishiura, Akemi Ishida, Yamamoto, Takashi, Hashimoto, Kunihiko, Tamaki   +6 more
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ELISA detection of anti‐desmoglein 1 and anti‐desmoglein 3 and indirect immunofluorescence in oral pemphigus: A retrospective study

Oral Diseases, 2021
Abstract Objective The aim of this study was to test the efficacy of autoantibodies to desmoglein 1 and desmoglein 3 detected by ELISA and indirect immunofluorescence in the diagnosis of oral pemphigus and to correlate the antibody titres with the severity of the disease.
Massimo Petruzzi, Alberta Lucchese, Maria Contaldo, Marilina Tampoia, Maria Antonia Frassanito, Dorina Lauritano, Fedora della Vella   +6 more
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Expression of pemphigus‐autoantigen desmoglein 1 in human thymus

Tissue Antigens, 2008
AbstractDesmoglein (Dsg) 1 is a transmembrane glycoprotein of the desmosome allowing cell–cell adhesion between keratinocytes, whose expression is restricted to stratified squamous epithelia‐like epidermis. Dsg1 is the target autoantigen of pathogenic autoantibodies produced by pemphigus foliaceus and 50% of pemphigus vulgaris patients in a Dsg1 ...
H, Mouquet, S, Berrih-Aknin, J, Bismuth, P, Joly, D, Gilbert, F, Tron   +5 more
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Split stories converge at desmoglein 1.

Nature Medicine, 2000
The exact mechanism by which exfoliative toxin A (ETA), producedby Staphylococcal aureus, causes epidermal blistering has been elusive.A combined knowledge of the pathogenesis of pemphigus, cell adhesion mechanisms,and the amino acid sequence of ETA led to a simple answer (pages 1275–1277 ).
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Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion

Differentiation, 2004
Desmoglein 1 (Dsg1) is a component of desmosomes present in the upper epidermis and can be targeted by autoimmune antibodies or bacterial toxins, resulting in skin blistering diseases. These defects in tissue integrity are believed to result from compromised desmosomal adhesion; yet, previous attempts to directly test the adhesive roles of desmosomal ...
Spiro, Getsios, Evangeline V, Amargo, Rachel L, Dusek, Ken, Ishii, Linda, Sheu, Lisa M, Godsel, Kathleen J, Green   +6 more
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Staphylococcus hyicus exfoliative toxins selectively digest porcine desmoglein 1

Microbial Pathogenesis, 2005
Virulent strains of Staphylococcus hyicus can cause exudative epidermitis in pigs. The major symptom of this disease is exfoliation of the skin in the upper stratum spinosum. Exfoliation of the skin is strongly associated with exfoliative toxin including ExhA, ExhB, ExhC, ExhD, SHETA, and SHETB. Recently, genes for ExhA, ExhB, ExhC and ExhD were cloned.
Yasuyuki, Fudaba, Koji, Nishifuji, Lars Ole, Andresen, Takayuki, Yamaguchi, Hitoshi, Komatsuzawa, Masayuki, Amagai, Motoyuki, Sugai   +6 more
openaire   +2 more sources