Results 71 to 80 of about 12,732 (174)

Desmosomes:  Essential contributors to an integrated intercellular junction network [version 1; peer review: 2 approved]

F1000Research, 2019
The development of adhesive connections between cells was critical for the evolution of multicellularity and for organizing cells into complex organs with discrete compartments. Four types of intercellular junction are present in vertebrates: desmosomes,
Kathleen J Green, Avinash Jaiganesh, Joshua A Broussard   +2 more
doaj   +1 more source

Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Frontiers in Immunology, 2018
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth, Volker Spindler, Jens Waschke   +2 more
doaj   +1 more source

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection

Frontiers in Cellular and Infection Microbiology, 2018
Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases.
Tomoko Sumitomo, Yasushi Mori, Yasushi Mori, Yuumi Nakamura, Mariko Honda-Ogawa, Seitaro Nakagawa, Masaya Yamaguchi, Hiroyuki Matsue, Yutaka Terao, Masanobu Nakata, Shigetada Kawabata   +10 more
doaj   +1 more source

Desmosomes in pemphigus vegetans

Acta Dermato-Venereologica, 1981
Desmosomes of a patient suffering from pemphigus vegetans were studied by electron microscopy and analysed by morphometry, The desmosomes were fewer in the patient´s skin than in healthy individuals. The desmosomes of the patient were thin and short, showing pathological ultrastructures, viz.
T, Higashida, H, Hino, T, Kobayasi
openaire   +2 more sources

Structure of Desmosomes

, 2015
Desmosomes are cell-cell junctions that connect neighboring cells to their intermediate filament networks that serve to provide mechanical strength to the tissue. Major proteins that compose desmosomes are desmogleins, desmocollins, plakoglobin, plakophilins and desmoplakin.
openaire   +2 more sources

Dsg2 ectodomain organization increases throughout desmosome assembly

Cell Adhesion & Migration
Desmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F. Dean, Rose M. Albert, Tomasz J. Nawara, Melanie Ubil, Reena R. Beggs, Alexa L. Mattheyses   +5 more
doaj   +1 more source

The desmosome and pemphigus

Histochemistry and Cell Biology, 2008
Desmosomes are patch-like intercellular adhering junctions ("maculae adherentes"), which, in concert with the related adherens junctions, provide the mechanical strength to intercellular adhesion. Therefore, it is not surprising that desmosomes are abundant in tissues subjected to significant mechanical stress such as stratified epithelia and ...
openaire   +2 more sources

Desmosomes and disease.

Histology and histopathology, 1997
Considerable progress has been made in our knowledge of desmosomes and their components. Molecular cloning of the desmosomal glycoproteins has established that desmoglein 1 and desmoglein 3 are targets for autoantibodies in the blistering diseases pemphigus foliaceus and pemphigus vulgaris respectively.
openaire   +2 more sources

Caspase-activation powers anti-Desmoglein 3-induced acantholysis in human epidermis. [PDF]

Cell Death Discov
Schmidt MF, Feoktistova MA, Panayotova-Dimitrova D, Buhl EM, Boor P, Ruhl T, Waschke J, Tikkanen R, Röcken M, Baron JM, Yazdi AS.   +10 more
europepmc   +2 more sources