Results 81 to 90 of about 12,991 (180)

The role of desmosomes in carcinogenesis

OncoTargets and Therapy, 2017
Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression.
Guangxin Zhou, Linlin Yang, Ashley Gray, Amit Kumar Srivastava, Cuiping Li, Gongwen Zhang, Tiantian Cui   +6 more
openaire   +4 more sources

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Biochemical Characterization of the Desmosome [PDF]

Journal of Investigative Dermatology, 2007
Bass-Zubek, Amanda E., Green, Kathleen J.   +1 more
openaire   +3 more sources

Exploring the potential relevance of microRNAs targeting the ARVC-related gene interaction network to cancer: an in silico testing hypothesis

Journal of Biological Research - Thessaloniki
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the myocardium. Mutations in the PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN and DES genes which encode proteins of the cardiac desmosome have been linked to the disease yet, the
Athanasios Balaskas, Argyris Dallis, Sotirios G Zarogiannis, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Erasmia Rouka   +5 more
doaj   +1 more source

Erratum: SIRT1 activation and its effect on intercalated disc proteins as a way to reduce doxorubicin cardiotoxicity

Frontiers in Pharmacology, 2023
Frontiers Production Office
doaj   +1 more source

Dsg2 ectodomain organization increases throughout desmosome assembly

Cell Adhesion & Migration
Desmosomes are intercellular junctions that regulate mechanical integrity in epithelia and cardiac muscle. Dynamic desmosome remodeling is essential for wound healing and development, yet the mechanisms governing junction assembly remain elusive.
William F. Dean, Rose M. Albert, Tomasz J. Nawara, Melanie Ubil, Reena R. Beggs, Alexa L. Mattheyses   +5 more
doaj   +1 more source

CCDC120 phase separation contributes to desmosomal integrity and cardiac function

Nature Communications
Desmosomes are cell-cell adhesive junctions that provide structural integrity and mechanical resistance to tissues. Disruptions in desmosome organization lead to severe cardiac and dermatological disorders.
Hui Meng, Wei Zhao, Yangyingzi Xi, Donghui Zhang, Xipan Han, Rixu Cong, Tianning Wang, Yingchun Hu, Yonglu Tian, Linwen Gong, Xiaopeng Zou, Junlin Teng, Jianguo Chen, Ning Huang   +13 more
doaj   +1 more source

Desmosomes compartmentalize mRNA and translation in the skin. [PDF]

Dev Cell
D'Alessandro A, Badu-Nkansah K, Link S, Hlavaty D, Bjerke G, Nicchitta CV, Yi R, Lechler T.   +7 more
europepmc   +1 more source

Desmosome [PDF]

, 2020
openaire   +1 more source

Desmosomal-Type Acantholysis-A New Histologic Pattern Related to Mutations of Genes for Desmosomal Proteins. [PDF]

Dermatopathology (Basel)
Metze D, Süßmuth K, Metze C, Oji V, Traupe H.   +4 more
europepmc   +1 more source