Results 101 to 110 of about 14,857 (218)

Disrupted desmosomes in induced lesions of familial benign chronic pemphigus

, 1979
An occlusive dressing was applied to the unaffected skin of the back of a patient with familial benign chronic pemphigus (FBCP). Small lesions of FBCP appeared after 48 h, and the ultrastructure of successive biopsies was studied. It was concluded that: (
Achten, Georges, De Dobbeleer, Gilbert
core   +1 more source

Desmin-p.L112Q Disturbs Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated Cardiomyopathy

Journal of Cardiovascular Development and Disease
DES encodes the muscle-specific intermediate filament protein desmin, which is highly relevant to the structural integrity of cardiomyocytes. Mutations in this gene cause different cardiomyopathies including dilated cardiomyopathy.
Alexander Lütkemeyer, Sabrina Voß, Jonas Reckmann, Joline Groß, Anna Gärtner, Jan Gummert, Hendrik Milting, Andreas Brodehl   +7 more
doaj   +1 more source

The role of desmosomes in carcinogenesis

OncoTargets and Therapy, 2017
Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression.
Guangxin Zhou, Linlin Yang, Ashley Gray, Amit Kumar Srivastava, Cuiping Li, Gongwen Zhang, Tiantian Cui   +6 more
openaire   +4 more sources

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

Atomic Force Microscopy Provides New Mechanistic Insights into the Pathogenesis of Pemphigus

Frontiers in Immunology, 2018
Autoantibodies binding to the extracellular domains of desmoglein (Dsg) 3 and 1 are critical in the pathogenesis of pemphigus by mechanisms leading to impaired function of desmosomes and blister formation in the epidermis and mucous membranes. Desmosomes
Franziska Vielmuth, Volker Spindler, Jens Waschke   +2 more
doaj   +1 more source

Effective Management of Recalcitrant Hailey–Hailey Disease With Risankizumab

International Journal of Dermatology, Volume 65, Issue 7, Page 1457-1459, July 2026.
Joy Justice, Adriana Della Porta, Eva Niklinska, Jami L. Miller   +3 more
wiley   +1 more source

Chapter 18 Visualization of Desmosomes in the Electron Microscope

, 2008
Desmosomes are intercellular junctions found in epithelia and some other tissues. Their primary function is strong cell-cell adhesion. They also link the intermediate filament (IF) cytoskeletons between cells and have roles in cell signaling, tissue ...
Anthea Scothern, Scothern, Anthea, Garrod, David, David Garrod   +3 more
core   +1 more source

Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection

Frontiers in Cellular and Infection Microbiology, 2018
Streptococcus pyogenes is responsible for a wide variety of cutaneous infections ranging from superficial impetigo to fulminant invasive necrotizing fasciitis. Dysfunction of desmosomes is associated with the pathogenesis of cutaneous diseases.
Tomoko Sumitomo, Yasushi Mori, Yasushi Mori, Yuumi Nakamura, Mariko Honda-Ogawa, Seitaro Nakagawa, Masaya Yamaguchi, Hiroyuki Matsue, Yutaka Terao, Masanobu Nakata, Shigetada Kawabata   +10 more
doaj   +1 more source

A study of desmosomes in human colorectal cancer

, 1989
Reduction in adhesiveness of malignant cells may promote invasion or cell detachment, contributing to the formation of metastases. Desmosomes are adhesive intercellular junctions, characteristic of vertebrate epithelia.
Marston, Jane Elizabeth
core  

Changes in the desmosomes of lymphatic vessel endothelial cells as shown by electron microscopy.

, 2013
(a) Desmosomes in the normal type. In a three-dimensional structure, they adhere to the adjacent lymphatic vessel endothelial cells. Bar = 2 µm. (a’) Magnified image. Bar = 2 µm.
Takeshi Todokoro (314536), Noriyuki Murai (160386), Hisako Hara (160364), Taro Okitsu (160391), Takuya Iida (160381), Jun Araki (138191), Kazuki Kikuchi (160371), Makoto Mihara (138200), Isao Koshima (138203), Iori Kisu (170427), Mitsunaga Narushima (160375), Yohei Hayashi (236734), Takumi Yamamoto (160379), Naoya Sawamoto (314538)   +13 more
core   +1 more source