Results 101 to 110 of about 15,816 (206)

Assessment of Phenotype, Oxidative Stress and Biomacromolecule Oxidation in Human Chronic Skin Wound Epidermis in Active Debridement Tissue Versus Endstage Wounds

Wound Repair and Regeneration, Volume 34, Issue 5, September/October 2026.
ABSTRACT Impairment of cutaneous healing occurs in association with numerous comorbidities including diabetes, vascular insufficiency and immobility. Standard management of chronic wounds includes removal of necrotic tissue and infection management, but no biomarkers are used to guide appropriate debridement distance.
Dylan Tinney, Justin Carmichael, Punkuj Chawla, David Keast, Douglas W. Hamilton   +4 more
wiley   +1 more source

Desmosomes in pemphigus vegetans

Acta Dermato-Venereologica, 1981
Desmosomes of a patient suffering from pemphigus vegetans were studied by electron microscopy and analysed by morphometry, The desmosomes were fewer in the patient´s skin than in healthy individuals. The desmosomes of the patient were thin and short, showing pathological ultrastructures, viz.
T, Higashida, H, Hino, T, Kobayasi
openaire   +2 more sources

Gene mutations resulting in the development of ARVC/D could affect cardiac pacemaker and conductive tissue

Frontiers in Physiology, 2012
In contrast to epithelial cells, cardiomyocytes are connected by complex hybrid-type adhering junctions, termed composite junctions (areae compositae).
Sebastian ePieperhoff
doaj   +1 more source

The role of desmosomes in carcinogenesis

OncoTargets and Therapy, 2017
Desmosomes, which are intercellular adhesive complexes, are essential for the maintenance of epithelial homeostasis. They are located at the cell membrane, where they act as anchors for intermediate filaments. Downregulation of desmosome proteins in various cancers promotes tumor progression.
Guangxin Zhou, Linlin Yang, Ashley Gray, Amit Kumar Srivastava, Cuiping Li, Gongwen Zhang, Tiantian Cui   +6 more
openaire   +4 more sources

Hyper-adhesion in desmosomes: Its regulation in wound healing and possible relationship to cadherin crystal structure

, 2005
The resistance of tissues to physical stress is dependent upon strong cell-cell adhesion in which desmosomes play a crucial role. We propose that desmosomes fulfil this function by adopting a more strongly adhesive state, hyper-adhesion, than other ...
Tabernero, Lydia; id_orcid, Garrod, David R., Berika, Mohamed Y., Holmes, David, Bardsley, William F.   +4 more
core   +1 more source

Tyrosine phosphorylation in desmosomes and hemidesmosomes of the corneal epithelium.

, 1996
We examined the localization of phosphotyrosine (p-Tyr)-modified proteins in the normal corneal epithelium using affinity-purified rabbit anti-p-Tyr antibody.
M Takahashi, T Fujimoto, K Amino, Y Honda   +3 more
core   +1 more source

Desmosomes: adhesive strength and signalling in health and disease

, 2010
Desmosomes are intercellular junctions whose primary function is strong intercellular adhesion, known as hyperadhesion. In the present review, we discuss how their structure appears to support this function as well as how they are assembled and down ...
Anthea Scothern, Helen A. Thomason, Selina McHarg, David R. Garrod   +3 more
core   +1 more source

Biochemical Characterization of the Desmosome [PDF]

Journal of Investigative Dermatology, 2007
Bass-Zubek, Amanda E., Green, Kathleen J.   +1 more
openaire   +3 more sources

A study of desmosomes in human colorectal cancer

, 1989
Reduction in adhesiveness of malignant cells may promote invasion or cell detachment, contributing to the formation of metastases. Desmosomes are adhesive intercellular junctions, characteristic of vertebrate epithelia.
Marston, Jane Elizabeth
core   +1 more source

Exploring the potential relevance of microRNAs targeting the ARVC-related gene interaction network to cancer: an in silico testing hypothesis

Journal of Biological Research - Thessaloniki
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the myocardium. Mutations in the PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN and DES genes which encode proteins of the cardiac desmosome have been linked to the disease yet, the
Athanasios Balaskas, Argyris Dallis, Sotirios G Zarogiannis, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Erasmia Rouka   +5 more
doaj   +1 more source