Results 71 to 80 of about 15,816 (206)
A study of desmosomes in colorectal carcinoma
, 1990 Desmosomes are adhesive junctions of epithelial cells. Their expression may be altered or lost in carcinomas resulting in reduced cellular adhesiveness.
Collins, J.E. +5 more
core +1 more source
Andrology, EarlyView.ABSTRACT Background Pro‐inflammatory cytokines, TNF and IL‐1B, are essential for testicular homeostasis. Diacerein, an anti‐inflammatory drug, inhibits these cytokines, impairing M2 macrophages and Leydig cells (LCs). However, its impact on Sertoli cells (SCs) and M1 (CD68) macrophages remains unknown.
Elide Loise Freitas de Jesus +6 more
wiley +1 more source
Desmosome assembly, homeostasis, and desmosomal disease
Cell Health and Cytoskeleton, 2016 Nicola Cirillo1,2 1Melbourne Dental School and Oral Health CRC, The University of Melbourne, Melbourne, VIC, Australia; 2Research Unit, Centre for Innovation, Research, Education, and Health (IRIS), Caposele, Italy Abstract: Cell–cell adhesion is involved in all aspects of tissue behavior in multicellular organisms, from tissue morphogenesis (
openaire +4 more sources
Desmosome assembly and dynamics [PDF]
Trends in Cell Biology, 2013 Desmosomes are intercellular junctions that anchor intermediate filaments (IFs) to the plasma membrane, forming a supracellular scaffold that provides mechanical resilience to tissues. This anchoring function is accomplished by specialized members of the cadherin family and associated cytoskeletal linking proteins, which together form a highly ...
Oxana, Nekrasova, Kathleen J, Green
openaire +2 more sources
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Background Hailey‐Hailey disease (HHD) is a rare autosomal dominant blistering disorder caused by mutations in the ATP2C1 gene, which impair keratinocyte adhesion through disrupted calcium signaling. While traditionally considered a structural defect, recent studies suggest that Th2‐mediated inflammation may exacerbate disease pathology ...
Simonetta I. Gaumond +6 more
wiley +1 more source
Desmosomes in acquired disease [PDF]
Cell and Tissue Research, 2015 Desmosomes are cell-cell junctions that mediate adhesion and couple the intermediate filament cytoskeleton to sites of cell-cell contact. This architectural arrangement integrates adhesion and cytoskeletal elements of adjacent cells. The importance of this robust adhesion system is evident in numerous human diseases, both inherited and acquired, which ...
Sara N, Stahley, Andrew P, Kowalczyk
openaire +2 more sources
Cross-Talk between Adherens Junctions and Desmosomes Depends on Plakoglobin [PDF]
, 1997 Squamous epithelial cells have both adherens junctions and desmosomes. The ability of these cells to organize the desmosomal proteins into a functional structure depends upon their ability first to organize an adherens junction.
Keith R. Johnson +11 more
core +1 more source
Darier disease—A review highlighting new insights from the Darier Disease International Task Force
Journal of the European Academy of Dermatology and Venereology, EarlyView.This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz +49 more
wiley +1 more source
Ultrastructure of desmosomes in Rpgrip1l-/- mice.
, 2019 (a) Transmission electron microscopy micrographs of desmosomes between basal and suprabasal keratinocytes (Basal/suprabasal), and between spinous keratinocytes (Spinous) in E18.5 control (Rpgrip1l+/+) and homozygous (Rpgrip1l-/-) mutant (n = 7 mice ...
Jiang Chen (583708) +17 more
core +1 more source
POF1B Localizes to Desmosomes and Regulates Cell Adhesion in Human Intestinal and Keratinocyte Cell Lines [PDF]
, 2015 By means of morphological and biochemical criteria, we here provide evidence for the localization and function of premature ovarian failure, 1B (POF1B) in desmosomes.
A. Crespi +15 more
core +1 more source