Results 71 to 80 of about 12,991 (180)
Brain Pathology, Volume 36, Issue 5, September 2026.Untargeted multiomic profiling of cerebrospinal fluid reveals that proteomic, but not lipidomic, signatures robustly distinguish ALS patients from controls and stratify individuals by survival, highlighting marked molecular differences between short survival and long survival disease.
Sergio Roca‐Pereira +19 more
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American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1807-1813, August 2026.ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg +9 more
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Clinical Case Reports, Volume 14, Issue 8, August 2026.ABSTRACT Desmin, a crucial intermediate filament in muscle cells, maintains structural integrity in cardiac muscle and provides stability to striated muscle cells. Mutations in the DES gene lead to desminopathies, causing diverse cardiac and skeletal myopathies.
Saeideh Kavousi +5 more
wiley +1 more source
Journal of Arrhythmia, Volume 42, Issue 4, August 2026.ECG parameters, particularly depolarization‐based markers, demonstrate high specificity for differentiating ARVC from idiopathic outflow tract arrhythmias. A multi‐marker ECG approach may facilitate accessible early screening and clinical decision‐making, particularly in settings with limited access to advanced imaging.
Erika Maharani +5 more
wiley +1 more source
AP‐1B Controls Several Levels of Cell Proliferation and Differentiation in Mouse Enteroids
Biology of the Cell, Volume 118, Issue 8, August 2026.We show that in mouse intestinal organoids, AP‐1B is implicated in apical polarity, differentiation in the secretory lineage and proliferation. In particular, we propose that proliferation is controlled by AP‐1B via the mTOR and YAP pathways. Arrows show the functional links that were elucidated in this study, and dotted lines show putative downstream ...
Maela Duclos +5 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Partial hepatectomy (PH) reshapes gut microbiota composition, resulting in the release of microbial metabolites and components, including short chain fatty acids (SCFAs)/β‐hydroxybutyric acid (BHB), bacterial DNA and extracellular vesicles (EVs), bile acids (deoxycholic acid, DCA), and aminobenzoate degradation products.
Roberto Loi +3 more
wiley +1 more source
Desmosomes in pemphigus vegetans
Acta Dermato-Venereologica, 1981 Desmosomes of a patient suffering from pemphigus vegetans were studied by electron microscopy and analysed by morphometry, The desmosomes were fewer in the patient´s skin than in healthy individuals. The desmosomes of the patient were thin and short, showing pathological ultrastructures, viz.
T, Higashida, H, Hino, T, Kobayasi
openaire +2 more sources
Фактори експериментальної еволюції організмів, 2017 Aim. In our present work, we have addressed to the γ-catenin, known main component of desmosomes, expression in hearts with heterozygous and homozygous knockout of α-E-catenin gene. Methods. Alpha-E-catenin conditional knockout mice were bred with α-MHC-
V. V. Balatskyi +2 more
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Histology and histopathology, 1997 Considerable progress has been made in our knowledge of desmosomes and their components. Molecular cloning of the desmosomal glycoproteins has established that desmoglein 1 and desmoglein 3 are targets for autoantibodies in the blistering diseases pemphigus foliaceus and pemphigus vulgaris respectively.
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F1000Research, 2019 The development of adhesive connections between cells was critical for the evolution of multicellularity and for organizing cells into complex organs with discrete compartments. Four types of intercellular junction are present in vertebrates: desmosomes,
Kathleen J Green +2 more
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