Results 91 to 100 of about 376,084 (233)
Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue [PDF]
A crucial and challenging aspect of the drug development process is the requirement to measure the distribution of a pharmaceutical compound and its metabolites in tissue.
Blatherwick, Eleanor Q.
core
, 2016 Desorption electrospray ionization - mass spectrometry (DESI-MS) imaging was used to analyze unmodified human brain tissue sections from 39 subjects sequentially in the positive and negative ionization ...
Alan Jarmusch +5 more
core +1 more source
Quantifying protein-carbohydrate interactions using liquid sample desorption electrospray ionization mass spectrometry [PDF]
, 2015 The application of liquid sample desorption electrospray ionization mass spectrometry (liquid sample DESI-MS) for quantifying protein–carbohydrate interactions in vitro is described.
Yao, Yuyu +4 more
core +2 more sources
Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics
Mass Spectrometry Reviews, EarlyView.ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers +5 more
wiley +1 more source
Electrospray Vs Matrix-assisted Laser-desorption Ionization .1. Some Examples In the Protein Field
, 1994 Several proteins in the relative molecular mass (RMM) range 1150-29 000 are examined by means of both positive electrospray and matrix-assisted laser desorption/ionization mass spectrometry.
R. SERAGLIA +9 more
core +1 more source
Relative affinity constants by electrospray ionization and Fourier transform ion cyclotron resonance mass spectrometry: calmodulin binding to peptide analogs of myosin light chain kinase [PDF]
, 2003 Synthetic RS20 peptide and a set of its point-mutated peptide analogs have been used to analyze the interactions between calmodulin (CaM) and the CaM-binding sequence of smooth-muscle myosin light chain kinase both in the presence and the absence of Ca2+.
Lafitte, Daniel +3 more
core +1 more source
Using desorption electrospray ionization to study reaction intermediates
, 2011 We demonstrate that desorption electrospray ionization (DESI) can intercept reaction intermediates in solution on the millisecond timescale. Here we employ this method to study the reaction mechanisms of various organometallic complexes relevant to ...
Perry, Richard H. +2 more
core +1 more source
Mass Spectrometry Reviews, EarlyView.ABSTRACT Identification of a chemical agent yields insights into its physicochemical properties. By examining the intrinsic characteristics and environment of a compound, information about its history can be gathered. The main objective of authentication/forensic approaches to chemicals is to trace the history of the compound's origin, regardless of ...
Carla Orlandi +6 more
wiley +1 more source
, 2014 Nanospray desorption electrospray ionization (nano-DESI) is an ambient ionization technique that uses localized liquid extraction for mass spectrometry imaging of molecules on surfaces.
Lanekoff, Ingela, +3 more
core +1 more source
Mass Spectrometry Imaging–Guided Proteomics, an Emerging Frontier in Spatial Biology
Mass Spectrometry Reviews, EarlyView.ABSTRACT Spatial heterogeneity is a defining feature of tissue organization, yet conventional proteomic analysis provides limited information about the spatial origins of identified proteins. Spatially guided proteomics addresses this limitation by using tissue imaging techniques to select regions of interest (ROIs) for localized analysis by liquid ...
Kenneth Weke +4 more
wiley +1 more source