Results 51 to 60 of about 613,223 (284)
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Formation of the Inbound Tourism Business Ecosystem:
Maketingu Janaru, 2020 Who and what comprise the tourism business ecosystem for the Japanese tourism market in Hawaii? To answer this question, this paper focused on the behavior of an international tour operator (JTB Hawaii) and conducted a case study from the viewpoint of ...
Chiharu Kashiwagi
doaj +1 more source
THE POTENTIALS AND POSSIBILITIES FOR DEVELOPMENT OF TOURISTIC OFFER IN EASTERN MACEDONIA [PDF]
Journal of Process Management and New Technologies, 2016 The research of the touristic offer market indicates that the previous touristic arrangements that included a touristic offer of seven or fourteen days is not an attractive offer nowadays.
Nikola Bizoev
doaj +1 more source
Aptisi Transactions on Technopreneurship, 2023 This research focuses on the high urgency of utilizing Artificial Intelligence (AI) and the Internet of Things (IoT) to enhance Smart Tourism Destinations (STDs).
Aliyah +4 more
doaj +1 more source
, 2018 This book focuses on the planning, marketing, and management of Asian tourism destinations, and evaluates current developments within Southeast-Asia and the wider Asia-Pacific region.
Wang, Ying +3 more
openaire +2 more sources
What does generation Y want from conferences and incentive programmes? [PDF]
, 2008 This article examines the particular characteristics of Generation Y, such as their high expectations, their desire for ongoing education and their technological aptitude.
Davidson, Rob
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
TOURIST DESTINATION MANAGEMENT
Revista de Turism: Studii si Cercetari in Turism, 2009 Tourism development has environmental and social consequences upon local and global communities. The impact of tourism must be kept within certain limits which are set up by sustainable tourism. Meanwhile the viability of the investment must be assured. Tourism development matrix is the tourist destination.
openaire +5 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source